表皮生长因子影响肿瘤患者舌苔变化的分子机制研究  

Molecular mechanism of the effects EGF on tongue fur of tumor patients

作　　者：许冬青[1] 王明艳[1] 狄洌[2] 詹瑧[1] 

机构地区：[1]南京中医药大学基础医学院微生物学与免疫学教研室,江苏南京210029 [2]南京农业大学理学院

出　　处：《细胞与分子免疫学杂志》2002年第6期598-600,共3页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金资助No .3 0 0 70 910

摘　　要：目的　研究表皮生长因子 (EGF)对食管癌细胞Eca 10 9细胞周期及表皮生长因子受体 (EGF R)表达的影响 ,探讨EGF促进肿瘤患者舌苔增厚的分子机制。方法　应用流式细胞术 ,检测EGF R的表达和细胞周期。结果　EGF能明显促进Eca 10 9细胞膜上EGF R的表达 ,使细胞增殖活性大大增强。结论　EGF有可能是通过促进EGFAim To investigate the effects of epidermal growth factor (EGF) on cell cycle and EGF R expression of esophagus carcinoma cell line Eca 109 and explore molecular mechanism of influencing tongue fur of the tumor patients by EGF. MethodThe expression of EGF R and cell cycle of Eca 109 cells were detected by flow cytometry(FCM). Results EGF could significantly up regulate increase the expression of EGF R and enhance the proliferation of Eca 109 cells. Conclusion Increased expression of EGF R may be a main cause of enhancemant of tongue fur formation by EGF.

关 键 词：分子机制 表皮生长因子 细胞周期 流式细胞术 舌苔 食管癌 

分 类 号：R273.51[医药卫生—中西医结合]