异丙酚复合小剂量芬太尼在心脏麻醉中的应用  

Propofol combined with a small dose fentanyl in patients undergoing cardiac surgery

作　　者：周艳平[1] 郭曲练[1] 蔡宏伟[1] 刘瑶[1] 

机构地区：[1]中南大学湘雅医院麻醉科,长沙410008

出　　处：《湖南医科大学学报》2002年第5期468-470,共3页Bulletin of Hunan Medical University

摘　　要：目的 :观察异丙酚复合小剂量芬太尼对心脏术后早期拔管的影响。方法 :6 0例择期房室缺修补手术病人 ,随机分成芬太尼组 (F组 )和异丙酚组 (P组 )。F组使用中剂量芬太尼 (30～ 35 μg·kg- 1 )。P组使用小剂量芬太尼(15～ 2 0 μg·kg- 1 )及持续静脉泵注异丙酚 (4～ 6mg·kg- 1 ·h- 1 )。两组维库溴胺及咪唑安定用法相同。结果 :两组病人血流动力学参数变化差异无显著性 (P >0 .0 5 ) ,P组拔管的时间明显短于F组 (P <0 .0 5 ) ,术后呕吐发生率呈减低趋势。结论 :房室缺修补术患者术中 ,异丙酚 4～ 6mg·kg- 1 ·h- 1Objective To observe the effects of propofol with a small dose of fentanyl on early extubation in patients undergoing cardiac surgery. Methods Sixty patients undergoing elective antrium and ventricle septum deficincy (ASD, VSD) surgery were randomly put into two groups: fentanyl group (F group) and propofol group (P group). The total dose of fentalyl was 30～35 μg·kg -1 in the F group. The total dose of fentanyl was 15～20 μg·kg -1 in the P group; propofol was given at the rate of 4～6 mg·kg -1 ·h -1 intravenously in the P group. The use of vecuronium and midazolum in the two groups was the same. Results There was no significant difference in hemodynamic changes between the two groups (P>0.05). The extubation time of the P group was significantly shorter than that of the F group (P<0.05). The rate of post operation vomit occurrence was decreased. Conclusion It is useful for early extubation that propofol is given at the rate of 4～6 mg·kg -1 ·h -1 intravenously combined with a small dose of fentanly in patients undergoing ASD and VSD surgery.

关 键 词：异丙酚 芬太尼 血流动力学 麻醉学 

分 类 号：R614.2[医药卫生—麻醉学]