大黄提取片对单纯性肥胖大鼠高胰岛素血症的作用  

Effect of Tablet Extracted from Rhubarb on Hyperinsulinemia in Simple Obese Rats

作　　者：高雅萍 焦东海 王梅莉 王秀莲 金惠铭[2] 陈愉[2] 曲晓义[2] 张国平[2] 

机构地区：[1]上海市香山中医医院及上海市中西医结合肥胖病医疗协作中心,上海200020 [2]复旦大学医学院病理生理学教研室,上海200032

出　　处：《中国实验方剂学杂志》2002年第6期29-31,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的 :研究大黄提取片对单纯性肥胖SD大鼠高胰岛素血症的作用。方法 :口服给药 ,剂量 :2ml 0 2 5g 10 0gB .W . 日 ,高胰岛素血症 (空腹胰岛素水平 >2 5 μu ml)治疗组肥胖大鼠 8只 ,高胰岛素血症对照组肥胖大鼠 8只。血清胰岛素及C肽测定用放免法 ,血清TNFα 测定用ELISA法。结果 :用药一个月后实验治疗组肥胖大鼠减肥同时高胰岛素血症者血清胰岛素及C肽明显降低。TNFα 明显降低 ,血清胰岛素与血清TNFα 间呈显著正相关。结论 :大黄提取片对单纯性肥胖大鼠减肥的同时高胰岛素血症改善 ,此作用与血清TNFαAim:To study effect of the tablet extracted from rhubarb on hyperinsulinmia in simple obese rats.Methods:The simple obese rats with hyperinsulinmia were randomly divided into two groups:experimental group was composed of eight rats,administrated with tablet extracted from rhubarb,0.25g/100gb.w/day,control group:eight rats,administrated with N.S.The serum insulin and peptide C were detected by radioimmunoassay,the serum TNF\|α by ELISA.Results:After administration of tablet extracted from rhubarb for one month,the body weight in experimental rats was obviously reduced,at the same time,the level of insulin,peptide C and TNF\|α remarkably lowered.There is a positive relationship between the serum insulin and TNF\|αlevel.Conclusion:The tablet extracted from rhubarb demonstrated significant effects on reducing body weight and lowering the serum insulin level in hyperinsulinmia in simple obese rats,which may be contributed to the decrease of TNF α level

关 键 词：肥胖 大黄提取片 高胰岛素血症 TNF 中药 药理 

分 类 号：R285.5[医药卫生—中药学]