罕见染色体复杂易位伴不良孕育史四例  

Analysis of 4 abnormal pregnancy cases with complex chromosomal rearrangement

作　　者：刘露[1] 罗小金[1,2] 郭岩芸 王绍娟[3] 

机构地区：[1]遵义医学院研究生院,563000 [2]广东省深圳市龙岗区妇幼保健院 [3]广东省深圳市龙岗区人民医院

出　　处：《妇产与遗传（电子版）》2015年第3期20-23,共4页Obstetrics-Gynecology and Genetics (Electronic Edition)

摘　　要：目的探讨伴不良孕育史的罕见染色体复杂易位患者流产的病因,为患者孕育提供建议。方法回顾2013年5月至2015年5月广东省深圳市龙岗区妇幼保健院妇产科收治的发生自然流产患者的资料,检测其夫妇双方的染色体核型,并进行家系分析。结果4例患者均有自然流产病史,且夫妇一方确诊为染色体复杂易位。结论有复发性流产史或家族史的育龄夫妇,再生育前应行夫妻双方细胞遗传学检查。Objective To explore the etiology of abnormal pregnancy patients with complex chromosomal rearrangements and provide recommendations for future pregnancy. Methods The data karyotype and pedigree of cases with recurrent spontaneous abortion form May 2013 to May 2015 in Longgang Maternal and Child Health Hospital Shenzhen GuangdongProvincewereanalyzedretrospectively.Results 4patientshad a history of spontaneous abortion with one of the spouses diagnosed with complex chromosomal rearrangements. Conlusions Couples at reproductive age who have a history of recurrent spontaneous abortion or family history should conducted cytogenetic tests before pregnancy again.

关 键 词：易位 遗传 不良孕育史 复发性流产 

分 类 号：R714.21[医药卫生—妇产科学]