术中应用携氧液对高血压脑出血40例脑保护的研究  

Protective Effect of Oxygen-carrying Liquid on the Brain of Hypertensive Cerebral Hemorrhage during Operation

作　　者：王宁[1] 刘宏毅[2] 邹元杰[2] 孔洁[1] 

机构地区：[1]南京医科大学附属脑科医院麻醉科 [2]南京医科大学附属脑科医院神经外科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2002年第6期509-511,共3页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省卫生厅科研基金资助项目(S9701)

摘　　要：目的:研究高血压脑出血术中应用携氧液的脑保护作用。方法:高血压脑出血发病7h内的手术患者40例,随机分为2组:携氧液组(A组)和对照组(B组)。测定两组术中不同时段的颅内压(intracranialpressure,ICP),术前和术后12h血清髓鞘碱性蛋白(myelin-sheaghbasicityprotein,MBP)的浓度,术前和术后第7天的格拉斯哥(Glasgowcomascale,GCS)评分。结果:术中A组ICP明显低于B组。术后A组MBP浓度明显低于B组,A组GCS评分明显高于B组。结论:高血压脑出血术中应用携氧液有良好的脑保护作用。Objective: To study the protective effects of oxygen carrying liquid on the brain of hypertensive cerebral hemorrhage during operation. Methods: Forty patients of hypertention cerebral hemorrhage in operation were divided into two groups:group A (n=20) with oxygen carrying liquid and group B(n=20) the control group. ICP were monitored during operation. MBP plasma levels and the scores of GCS were measured before and after operation. Results: ICP in group A were significantly lower than that in group B. After operation, MBP plasma levels in group A were significantly lower than that in group B and the scores of BCS in group A were significantly higher than that in group B.Conclution: The oxygen carrying liquid had excellent protective effect on the brain of hypertensive cerebral hemorrhage during operation.

关 键 词：携氧液 高血压脑出血 脑保护 研究 静脉麻醉 

分 类 号：R651.12[医药卫生—外科学] R743.2[医药卫生—临床医学]