钝性胸部创伤后血浆ET-1、TNF-α及ANP变化的观察  

Observation of the changes of plasma ET-1, TNF-α and ANP in rabbits after blunt chest trauma

作　　者：闵家新[1] 朱佩芳[2] 王正国[2] 

机构地区：[1]第三军医大学附属新桥医院胸外科,重庆400037 [2]第三军医大学附属大坪医院野战外科研究所第四研究室,重庆400042

出　　处：《第三军医大学学报》2002年第11期1323-1324,共2页Journal of Third Military Medical University

基　　金：国家自然科学基金资助重点项目 ( 396 30 330 )

摘　　要：目的　探讨钝性胸部创伤 (BCT)后血浆部分细胞因子含量变化及意义。方法　随机选取兔 12只 ,采用BIM Ⅱ型生物撞击机致成BCT模型 ,分别在伤前、伤后 2、4、8、2 4h采血测定血浆内皮素 1(ET 1)、心钠素 (ANF)和肿瘤坏死因子 α(TNF α)含量。结果　伤后 2 4h血浆ET 1含量进行性增高 (P <0 0 1) ;ANF含量降低 ,伤后 8h降至最低 (P <0 0 5 ) ;TNF α含量在伤前后无明显变化 (P >0 0 5 )。结论　BCT后血浆部分细胞因子发生明显改变 ,这可能是BCT后引起器官功能障碍的原因之一。Objective To explore the changes and the significance of the cytokines in plasma after blunt chest trauma(BCT) in rabbits. Methods BCT model were established in 12 rabbits with BIM Ⅱ Bio impactor, and then the changes of the cytokines in plasma were observed at 2, 4, 8 h pre injury and 24 h post injury. Results The endothelins 1(ET 1) in plasma progressively increased at 24 h post-BCT(P<0.01) but the atrial natriuretic factor(ANF) decreased and bottomed out at 8 h post BCT( P <0.05). No changes of the tumor necrosis factor α(TNF α) was found after BCT( P >0.05). Conclusion The changed cytokine in plasma after BCT may be one of the causes leading to organ dysfunctions.

关 键 词：钝性胸部创伤 血浆 ET-1 TNF-Α ANP 

分 类 号：R655[医药卫生—外科学]