An Efficient Method for α-Alkylation of γ-Butyrolactone  

作　　者：YuanRuMENG YeDiGUAN 

机构地区：[1]DepartmentofChemistry,PekingUniversity,Beijing100871 [2]StateKeyLaboratoryofElemento－OrganicChemistry,NankaiUniversity,Tianjin300071

出　　处：《Chinese Chemical Letters》2002年第11期1039-1042,共4页中国化学快报（英文版）

摘　　要：This paper provides a simple, convenient and mild condition method for -alkylation of g-butyrolactone. Three types of (E)-a-alkenyl-g-butyrolactone compounds were synthesized by condensation of corresponding aldehydes and g-butyrolactone, using MeONa and EtONa as base. Then the a-alkyl-g-butyrolactones were gained by reducing the former alkenyl compounds through catalytic transfer hydrogenation under Pd/C catalyst with sodium hypophosphite at room temperature.This paper provides a simple, convenient and mild condition method for -alkylation of g-butyrolactone. Three types of (E)-a-alkenyl-g-butyrolactone compounds were synthesized by condensation of corresponding aldehydes and g-butyrolactone, using MeONa and EtONa as base. Then the a-alkyl-g-butyrolactones were gained by reducing the former alkenyl compounds through catalytic transfer hydrogenation under Pd/C catalyst with sodium hypophosphite at room temperature.

关 键 词：Alkylation of -butyrolactone CONDENSATION catalytic transfer hydrogenation Pd / C-sodium hypophosphite. 

分 类 号：O624.5[理学—有机化学]