Synthesis of N1-Substituted-3-aryl-4-alkyl-4, 5-dihydro-1H-1-pyra-zolethiocarboxamide as Novel Small Molecule Inhibitors of Cysteine Protease of T.cruzi  

作　　者：ChunGUO XiaoHuiDU 等 

机构地区：[1]SchoolofPharmaceuticalEngineering,ShenyangPharmaceuticalUniversity,Shenyang110016 [2]SchoolofPharmacy,UniversityofCalifornia,SanFrancisco,CA94143,U.S.A

出　　处：《Chinese Chemical Letters》2002年第11期1043-1046,共4页中国化学快报（英文版）

摘　　要：A series of N1-substituted-3-aryl-4-alkyl-4, 5-dihydro-1H-1-pyrazolethiocarboxamide were prepared from the Mannich bases of aryl ketones in good yields. Some derivatives were found to be active against the cysteine protease of T.cruzi..A series of N1-substituted-3-aryl-4-alkyl-4, 5-dihydro-1H-1-pyrazolethiocarboxamide were prepared from the Mannich bases of aryl ketones in good yields. Some derivatives were found to be active against the cysteine protease of T.cruzi..

关 键 词：N1-substituted-3-aryl-4-alkyl-4 5-dihydro-1H-1-pyrazolethiocarboxamide synthesis T.cruzi. cysteine protease inhibitor. 

分 类 号：O626.32[理学—有机化学] O629.711[理学—化学]