ASRR程序治疗131例绝经后骨质疏松症妇女的5年临床研究  

Five-year clinical study of DASRR programmed therapy of 131 postmenopausal osteoporotic women

作　　者：徐栋梁[1] 李佛保[1] 杨忠汉[1] 何爱珊[1] 黄芝胜[1] 

机构地区：[1]中山大学附属第一医院骨科,广州510080

出　　处：《中国骨质疏松杂志》2002年第4期321-323,共3页Chinese Journal of Osteoporosis

基　　金：国家教委博士点基金资助项目 ( 9754 ) ;国家卫生部(默沙东 )科研基金资助项目 ( 97 0 6 )

摘　　要：目的　观察DASRR程序治疗方案长期治疗绝经后骨质疏松症的疗效。方法　 1 31例绝经后骨质疏松症患者 ,用DASRR方案按程序先用二膦酸盐 2周 (羟乙膦酸钠 )或 4周 (阿仑膦酸钠 ) ,以抑制骨吸收活动 ;接着用氟化物 1个月 ,以刺激骨形成 ;再用活性维生素D3 及钙剂 1个月以加强成骨 ,停药 1个月自发诱导下一个骨代谢周期。再按上述程序重复周期。结果　通过 2～ 1 2个重复程序的治疗 ,骨密度 (BMD)多呈明显上升趋势 ,其中腰椎增加 1 3 41 % (P <0 0 5) ,双髋部平均BMD增加 9 36 % (P <0 0 5) ;骨折率逐年降低。结论　DASRR程序长期治疗绝经后骨质疏松症能更显著增加腰椎和髋部BMD 。Objective\ To investigate long\|term effect of DASRR programmed regime on postmenopausal osteoporotic women. Methods\ 131 osteoporotic women were subjected to the DASRR scheme.It began with bisphosphonate for 2 weeks(etidronate) or 4 weeks (alendronate) in order to depress bone resorptive activity,followed by fluoride for 1 month to stimulate bone formation,then vitamin D 3 combined with calcium to strengthen the bone mineralization and bone formation for 1 month,and then the medication stopped for 1 month to naturally initiate the next bone metabolic cycle. Results\ After 2 to 12 repeated courses(8 48 months),the bone mineral density(BMD) in the majority of patients increased significantly.Lumbar and mean both hip BMD increased 13\^41% and 9\^36% ( P <0 05) respectively by year 4.Fracture rates decreased year by year. Conclusion\ Lumbar and hip BMD increased and fracture rates decreased more significantly under long\|term DASRR programmed scheme in postmenopausal osteoporotic women.\;

关 键 词：DASRR程序 治疗 骨质疏松症 骨密度 绝经后妇女 疗效 

分 类 号：R681[医药卫生—骨科学] R711.75[医药卫生—外科学]