肝缺血再灌注与胃粘膜病理损伤  

Liver ischemia-reperfusion and pathological change of gastric mucosa

作　　者：褚延魁[1] 马庆久[1] 刘维[2] 鲁建国[1] 何显力[1] 杜锡林[1] 乔庆[1] 王胜智[1] 赵华栋[1] 

机构地区：[1]第四军医大学唐都医院普外科,陕西西安710038 [2]第四军医大学西京医院供应室,陕西西安710033

出　　处：《第四军医大学学报》2002年第21期1948-1951,共4页Journal of the Fourth Military Medical University

基　　金：唐都医院院基金项目 (1998)

摘　　要：目的　探讨肝缺血再灌注对胃粘膜的影响 .方法　SD大鼠 130只随机分为 3组 ,1假手术组 :术中只牵拉分离肝十二指肠韧带 ;2缺血再灌注组 :分为肝脏缺血 2 0 ,4 0 min2组 ,再灌注 1,2 4 ,72 h组 ;3肝缺血再灌注 +法莫替丁组 2mg· kg- 1 ,术后测定肝功 ,留取胃粘膜行光镜及电镜检查 ,观察胃粘膜病理变化 .结果　肝缺血再灌注后 ,伴随肝功损害 ,转氨酶升高 ,假手术组胃粘膜正常、缺血组出现水肿、充血及炎细胞浸润 .结论　肝缺血再灌注伴随远隔器官 -胃的损伤 ,胃粘膜以炎症性改变为主 .AIM To investigate the pathological change of gastric mucosa after liver ischemia reperfusion. METHODS 130 rats were divided randomly into 3 group: ① sham operation group; ② ischemia reperfusion (IR) group:ischemia time 20 min and 40 min, reperfusion time 1, 24 and 72 hgroup; ③ liver ischemia reperfsion rats treated with famotidine 2 mg·kg -1 group. Transarminases (ALT, AST) were detected after operation, pathomorphological changes of gastric mucosa were studied by light micrscope and transmission electronic microscope. RESULTS After ischemia reperfusion, ALT, AST increased significantly; pathological change of gastric mucosa in sham group was normal. But in IR group mucosa showed edemas, congestions, ulcers et al. CONCLUSION Liver ischeamia reperfusian can induce the pathological change in gastric mucosa and mainly showing inflammation procedures.

关 键 词：肝缺血再灌注 胃粘膜 病理损伤 动物模型 肝外科手术 

分 类 号：R657.3[医药卫生—外科学] R602[医药卫生—临床医学]