北京地区40例神经管缺损病因多因素分析  

AN ANALYSIS OF 40 CASES WITH NEURHL TUBE DEFECTS IN BEIJING DISTRICT

作　　者：芦春林[1] 阮明[1] 经永春 安笑兰[1] 

机构地区：[1]北京医科大学毒理教研室 [2]北医大第三医院妇产科

出　　处：《北京医科大学学报》1992年第2期141-144,共4页Journal of Peking University(Health Sciences)

基　　金：国家自然科学基金

摘　　要：本文对北京地区40例NTD进行了多因素调查分析,与80例正常对照和28例其他畸形对比,发现NTD发病与下列因素有关:孕早期接触有害化学物质、感染、发热、动物蛋白摄入量少等环境因素有关,有自发流产史和畸胎史的也占较大比例。孕产妇血清叶酸、锌和铜水平三组无差异。资料表明NTD病因是多因素的,在NTD高发区环境因素占有重要地位。A Multifactoral ctiology survey was carried out in 40 neural tube defects (NTD) cases, with 80normal controls and 28 with other malformations. There was a close relationship between NTD andthe following factors in the first trimester. such as: Exposure to poisonous chemicals (the NTD 25％,the other malformations 35.7%, the normal controls 1.25％, P<0.001), infection (the NTD 10%, theother malformations 17.9%, the controls 3.8％, P<0.05), fever (the NTD 10％, the other malforma-tions 7.1％, the normals 1.3％), and level of animal protein intake in NTD group was lower thanthat of normal group (P<0.05). The incidence of history of spontaneous abortion and malformationsin the NTD group was higher than that of the normal group (the NTD 15％, the normal 2.5％ andthe NTD 10％, the normal 1.3％, P<0.05 respectively). The serum levels of folic acid, Zn, Cu amongthe three groups had no significant difference. The data suggest that etiology of NTD is multifactoraland different in different individual. In areas with high incidence of NTD environmental factors playan important role.

关 键 词：神经管缺损 病因多因素 环境因素 

分 类 号：R714.53[医药卫生—妇产科学]