一种新型Au(Ⅲ)-吡啶酰胺配合物的合成,表征及其与5'-单磷酸鸟苷的反应研究  

Synthesis and Characterization of a Novel Au(Ⅲ)-Pyridine-Carboxamide Complex and its Reaction with 5'-GMP

作　　者：杨婷[1] 张俊勇[1] 涂超[1] 林骏[1] 刘琴[1] 郭子建[1] 

机构地区：[1]南京大学配位化学研究所,配位化学国家重点实验室,南京210093

出　　处：《无机化学学报》2003年第1期45-48,共4页Chinese Journal of Inorganic Chemistry

基　　金：教育部博士学科专项科研基金资助项目(No.20010284029)。

摘　　要：利用四氯合金酸和N-4-甲基苯基2-吡啶甲酰胺(HL)反应,合成得到了一种新的Au?配合物:二氯(N-4-甲基苯基2-吡啶甲酰胺合金?犤Au(L-N,N')Cl2犦。并通过元素分析、红外光谱、核磁共振谱、质谱及X-射线单晶衍射对其进行了表征。结构分析表明,Au?由二个氮原子和二个氯原子配位,呈平面四方形结构。质谱研究发现,该化合物与5'-单磷酸鸟苷(5'-GMP)反应生成犤Au(L-N,N')(5'-GMP)2犦。The Au?has the isoelectric structure to Pt?, and its complexes may possess potential antitumor activity. In this work we have synthesized and structurally characterized a novel Au?compound with N(4Methylphenyl)2pyridine carboxamide (HL) [Au(LN,N′)Cl2]. The Xray structural analysis shows that Au?is coordinated in a square planar geometry with two N atoms of the ligand and two Cl atoms. The compound is crystallized in monoclinic, space group is P2(1)/c with a=0.8464(2)nm, b=2.7823(6)nm, c=1.2161(2)nm, α= 90.000°, β=104.130(3)°, γ=90.000°. The ESMS data show that the Au?compound can react with 5′GMP to give rise formation of the bisGMP adduct [Au(LN,N′)(5′GMP)2]. CCDC: 194629.

关 键 词：三价金Au(Ⅲ) 合成 晶体结构 5’-GMP 

分 类 号：O614.123[理学—无机化学] O641.4[理学—化学]