阿莫西林钠/舒巴坦钠治疗急性细菌性感染21例  

Treatment of Acute Bacterial Infections with Amoxicillin/Sulbactam Sodium

作　　者：辛建保[1] 罗长清[2] 金阳[1] 姚丽君[2] 张建初[1] 傅玲[2] 邓安国[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院呼吸内科,武汉430022 [2]华中科技大学同济医学院附属协和医院肾病内科,武汉430022

出　　处：《医药导报》2003年第1期26-28,共3页Herald of Medicine

摘　　要：目的 :研究国产阿莫西林钠 舒巴坦钠治疗急性细菌性感染疾病的临床疗效和安全性。方法 :采用随机单盲对照试验设计 ,将 41例急性细菌性感染患者分为治疗组 2 1例 ,给予阿莫西林钠 舒巴坦钠 4.5～ 9.0g·d 1 ,对照组 2 0例 ,给予氨苄西林钠 舒巴坦钠 4.5～ 12 .0g·d 1 ,两组均分 2或 3次静脉滴注 ,疗程 7～ 14d。结果 :治疗组与对照组的痊愈率分别为 71.4% ,75 .0 % ,有效率 95 .2 %与 95 .0 % ,细菌阳性率 80 .9%与 90 .0 % ;产酶率 76.5 %与 66.7% ;细菌清除率94.1%与 94.4%。不良反应发生率为 9.5 %和 15 .0 % ,以上指标差异均无显著性 (P >0 .0 5 )。结论 :注射用阿莫西林钠 舒巴坦钠抗菌谱广 ,抗菌活性强 ,疗效确切 ,不良反应轻。Objective:To study the clinical effect and security of amoxicillin/sulbactam of China-produce in treating acute bacterial infections. Methods:By using the design of randomized single-blind controlled clinical trial, 41 patients were divided into two groups: trail group 21 and control group 20. The trial group was give, amoxillin/sulbactam 4.5-9.0g·d -1 , The control group was given ampicillin/sulbactam 4.5-12.0 g·d -1 , The drug injections being divided into 2 to 3 portions given by intravenous drip for both groups. Results:In the trail and the control groups, the recover rates were 71.4% and 75.0% respectively, the effectiveness rates were 95.2% and 95.0%, the positive bacterium rates were 80.9% and 90.0%, the rates of produced-enzyme were 76.5% and 66.7%, the rates of bacterium-clearance were 94.1% and 94.4%, and the incidences of adverse reaction were 9.5% and 15.0%. There was no significant difference about these parameters between the two groups ( P >0.05). Conclusion:Amoxicillin/sulbactam sodium for injection has a wide antibacterial spectrum, strong antibacterial activity, obvious curative effect and little adverse reaction.

关 键 词：急性细菌性感染 阿莫西林钠 舒巴坦钠 

分 类 号：R515[医药卫生—内科学] R978.11[医药卫生—临床医学]