中国人HLA-A和B位点血清学分型错误的分析  

Analysis of Serologic Typing Error for HLA-A and HLA-B in Chinese

作　　者：戴宇东[1] 孙启俊[1] 张益红[1] 袁红[1] 孟钵[1] 

机构地区：[1]南京红十字血液中心,南京210008

出　　处：《中国实验血液学杂志》2002年第5期455-457,共3页Journal of Experimental Hematology

摘　　要：对 2 7例HLA A和 B位点血清学分型错误进行分析。结果表明 ,HLA A和 B位点的误检型错误均高于漏检型错误 (P <0 .0 5) ,A和B位点分型间则无显著差别。中国人分型错误频率高的有A1 (66 .7% ) ,A3(50 .0 % ) ,A1 1 (1 3 .5 % ) ,A9(1 1 .8% )和A1 9(7.1 % )及B1 6(50 .0 % ) ,B48(43 .9% ) ,B1 5(1 6 .7% ) ,B40 (1 1 .1 % ) ,B1 3(1 0 .0 % )和B1 7(9.1 % )等抗原。结论Serological mistypings of HLA A and HLA B in 27 cases were analyzed. The results showed that for HLA A and HLA B typing, the rates of incorrect antigen assignments were significantly higher than rates of antigen misses (P<0.05), but there was no significant difference between HLA A and HLA B typings. The frequencies of miss assigned HLA A and HLA B specificities were A1(66.7%), A3(50.0%), A11(13.5%), A9(11.8%), A19(7.1%), and B16(50.0%), B48(43.9%), B15(16.7%), B40(11.1%), B13(10.0%) and B17(9.1%). In conclusion: the serologic and DNA based typing techniques should be reciprocally complementary in HLA A and HLA B typing.

关 键 词：HLA—A HLA—B 血清学分型 分型错误 中国人 

分 类 号：R457.2[医药卫生—治疗学]