重组人生长激素应用于烧伤治疗的临床评价  

Clinical evaluation of the effects of rhGH on the management of severely burned patients

作　　者：许辉 黄跃生[1] 彭毅志[1] 刘旭盛[1] 罗奇志[1] 田学功 刘晓冰 

机构地区：[1]第三军医大学西南医院全军烧伤研究所 [2]孝义市人民医院 [3]山西省兴县人民医院

出　　处：《中华烧伤杂志》2002年第5期288-291,共4页Chinese Journal of Burns

摘　　要：目的　观察重组人生长激素 (rhGH)用于烧伤治疗的有效性及安全性。　方法　在全国 5家烧伤单位 ,采用前瞻性同步随机对照方法 ,将伤后 5d内入院的烧伤面积 >2 0 %TBSA、年龄 2 0～ 5 5岁的 2 0 0例患者随机分成手术组和非手术组 ,每组再随机分为对照组 (N组 )、rhGH 0 .2U·kg-1·d-1治疗组 (A组 )和rhGH 0 .4U·kg-1·d-1治疗组 (B组 ) ,比较各组的一般情况、蛋白质与糖代谢变化、免疫功能、尿生化指标、创面愈合率及住院时间等。　结果　A、B两组与N组比较 ,血浆蛋白含量显著增加 ;免疫功能恢复较快 ;创面愈合时间明显缩短 ,愈合率明显提高 ;体重无明显变化 ;住院时间明显缩短 ,但血糖及胰岛素的浓度升高 ,尿钾、钠、氯的排出量减少。B组较A组疗效显著 ,但不良反应发生率相应增加。手术组不良反应发生率高于非手术组。　结论　rhGH能有效促进蛋白质合成 ,提高机体免疫功能 ,加快创面愈合 ,缩短住院时间 。Objective To investigate the effectiveness and the safety of clinical use of rhGH in the management of severe burn patients. Methods Two hundred burn patients aged 20 25 yrs with TBSA from 20% to 50% and admitted within 5 postburn days (PBD) were enrolled in this study. The patients were divided into operation and non operation groups. Furthermore, each group was randomly divided into control (N), treatment with rhGH in dosage 0.2 IU/Kg/d (A) and treatment with rhGH in dosage 0.4 IU/kg/d (B) groups. The general data , the metabolism of protein and glucose, the immune function , the urine biochemistry, the wound healing rate and hospital stay days recorded and compared among all groups. Results Plasma protein was increased, the immune function recovered early, the wound healing time was shortened obviously, the wound healing rate was increased evidently and the hospital stay days were decreased significantly in the treatment groups (A and B groups) compared with the N group. The body weight of burn patients remained unchanged in N group. Nevertheless, the plasma levels of glucose and insulin were increased and the urine output of potassium,sodium and chloride decreased in N group compared with those in A and B groups.Moreover,the levels of all these indices in B group were higher than those in A group,whereas side effects were more common in B group than in A group.In addition,the incidence of adverse reaction was higher in operation group than that in non operation group. Conclusion rhGH could effectively promote protein synthesis,enhance systemic immune function,accelerate wound healing and shorten hospital stay days in severely burned patients.But attention should be paid to appropriate dosage and duration of use. [

关 键 词：烧伤 免疫功能 代谢调理 创面修复 重组人生长激素 临床评价 

分 类 号：R644[医药卫生—外科学] R977.1[医药卫生—临床医学]