严重烧伤患者早期几种细胞因子的变化意义  

The significance of postburn changes in plasma levels of ICAM-1, IL-10 and TNFα during early postburn stage in burn patients

作　　者：匡新建[1] 马克娴[1] 段体武[1] 

机构地区：[1]昆明医学院附属第二医院烧伤科,南阳市中心医院烧伤科650101

出　　处：《中华烧伤杂志》2002年第5期302-304,共3页Chinese Journal of Burns

摘　　要：目的　观察细胞间粘附分子 1、白细胞介素 10及肿瘤坏死因子α在烧伤后并发症中的变化。方法　采用ELISA法检测严重烧伤早期 ,19例患者不同时相点外周血 3种细胞因子的水平及其变化 ,另选 11名健康志愿者为对照。　结果　 3种细胞因子的含量在伤后明显升高 ,合并有低血容量休克、脓毒血症或多器官功能障碍综合征 (MODS)时 ,升高更加明显 (P <0 .0 5～ 0 .0 1)。结论烧伤后早期动态监测 3种细胞因子的变化 ,对脓毒症及MODS的发生。Objective To observe the postburn changes in the plasma levels of ICAM 1, IL 10 and TNFα during early postburn stage. Methods Nineteen burn patients were enrolled in the study. The plasma levels of the above 3 kinds of factors were determined with ELISA in the peripheral plasma of the patients, plasma samples from 11 healthy volunteers were taken as the control. Results The plasma levels of ICAM 1, IL 10 and TNFα increased obviously postburn, especially in those patients who were complicated with hypovolumic shock, sepsis and MODS (P<0.05 0.01). Conclusion The monitoring of the postburn changes in plasma levels of ICAM 1, IL 10 and TNFα might be helpful in the forecast of postburn sepsis and the development of MODS. [

关 键 词：烧伤 胞间粘附分子1 白细胞介素10 肿瘤坏死因子 脓毒血症 多器官功能障碍综合征 

分 类 号：R644[医药卫生—外科学]