不同T细胞亚群对超抗原SEA反应性的差异  

Difference of Responsiveness in Murine T Cell Populations Reactive with Superantigen SEA

作　　者：张瑞华[1] 陈露秋[2] 储以微[1] 刘瑞梓[1] 王缨[1] 熊思东[1] 

机构地区：[1]复旦大学医学院免疫学系,上海200032 [2]东京女子医科大学微生物学与免疫学教研室

出　　处：《复旦学报（医学版）》2002年第6期437-439,共3页Fudan University Journal of Medical Sciences

摘　　要：目的　在体内和体外研究SEA再次刺激后Vβ3+ CD4+ 和Vβ3+ CD8+ T细胞亚群的免疫反应 ,探讨CD4+ 和CD8+ T细胞亚群对超抗原SEA反应性的差异。方法　分离小鼠超抗原金黄色葡萄球菌肠毒素A(SEA)应答性Vβ3+ CD4+ 和Vβ3+ CD8+ 两个T细胞亚群 ,检测其对SEA再次刺激的增殖反应及产生IL 2活性。结果　Vβ3+ CD4+ 和Vβ3+ CD8+ T细胞亚群对SEA再次刺激所诱导的增殖反应以及产生IL 2活性的能力有显著差异 (P <0 .0 1)。结论　SEA单次刺激时Vβ3+ CD4+ 和Vβ3+ CD8+ T细胞亚群反应性相似 ,再次刺激时Vβ3+ CD8+ 呈显著低反应性。Purpose: Examined the immunologic behaviors of (staphylococcal enterotoxin A, SEA) SEA-reactive two distinct T cell populations (Vβ3+ CD4+, Vβ3+ CD8+ T cells) in vivo and in vitro restimulated with SEA. Study the responsiveness of CD4+ and CD8+ T cell subsets reactive with superantigen SEA. Methods: Examined the proliferation and the IL-2 activity of the two purified murine SEA-reactive Vβ3+ CD4+ and Vβ3+ CD8+ T cell subsets that were restimulated with SEA. Results: Vβ3+ CD4+, Vβ3+ CD8+ T cells subsets showed significantly difference in proliferation and IL-2 activity restimulated with SEA (P+ CD4+ and Vβ3+ CD8+ T cell subsets in single SEA stimulation, but the responsiveness of Vβ3+ CD4+ and Vβ3+ CD8+ T cell subsets were changed in SEA restimulation.

关 键 词：T细胞亚群 超抗原SEA 反应性 差异 

分 类 号：R392.12[医药卫生—免疫学]