西洋参茎叶皂甙对CPHD病人外周淋巴细胞增强与调节作用  

Enhancement and modulation of PQS to peripheral lymphocytes from CPHD patients

作　　者：许力军[1] 刘超英[1] 段秀梅[2] 马艳玲[3] 

机构地区：[1]吉林大学第一医院呼吸科,长春130021 [2]吉林大学第一医院中心实验室,长春130021 [3]长春客车厂职工医院,长春130061

出　　处：《中国免疫学杂志》2002年第11期795-798,共4页Chinese Journal of Immunology

基　　金：吉林科技厅资助项目 (2 0 0 10 5 3 0 )

摘　　要：目的 :为了开发西洋参在临床医学方面的应用 ,提高CPHD病人的各项免疫指标。方法 :选择 4 0例CPHD病人 ,分成用药组 2 0例 ,对照组 (非用药组 ) 2 0例 ,通过流式细胞术检测病人外周血中T淋巴细胞亚群中各亚群所占的比例来反映机体的细胞免疫状态。结果 :通过两组临床研究观察 ,用药组疗效优于对照组 (P <0 0 5 )。西洋参茎叶皂甙可直接作用于淋巴细胞分化成熟过程 ,具有增强和调节CPHD病人机体免疫功能的作用。结论 :合理应用西洋参茎叶茎叶皂甙对改善CPHD病人免疫功能低下和紊乱状态 ,具有重要临床意义。Objective:To explore the application of PQS in clinics and improve immunological responses of CPHD patients.Methods:40 CPHD patients were selected,and were divided into two groups:exposure groups 20 cases,control group 20 cases.The proportion of subpopulations of T lymphocytes was determined through flow cytometry which reflected the level of cellular response.Results:Through clinical observations of two groups,effects of PQS in exposure group were better than that of control group(P<0.05).PQS can promote the proliferation and maturation of lymphocytes directly,improve and adjust the immune responses of CPHD patients.Conclusion:Proper applications of PQS to CPHD patients will improve the immune response activities and disorder state of the patients,and PQS is of great significance in clinical applications.

关 键 词：西洋参茎叶皂苷 外周淋巴细胞 调节作用 慢性肺心病 

分 类 号：R541.5[医药卫生—心血管疾病] R285.[医药卫生—内科学]