氟甲砜霉素(florfenicol)对禽败血支原体病的药效学  

Efficacy of Florfenicol Against Mycoplasma gallisepticum Infection in Broiler Chicken

作　　者：卜仕金[1] 郑月华[1] 蒋志伟[1] 甘军纪[1] 朱模忠 

机构地区：[1]扬州大学畜牧兽医学院,江苏扬州225009

出　　处：《中国兽医学报》2002年第6期607-608,共2页Chinese Journal of Veterinary Science

摘　　要：以试管两倍稀释法测得体外氟甲砜霉素 (florfenicol)及对照药物恩诺沙星对禽败血支原体 (MG)的最小抑菌质量浓度分别为 1.2 5、0 .0 195 mg/ L。体内药效试验表明 ,氟甲砜霉素以 30 0、40 0、5 0 0 mg/ kg饲料混饲给药 ,连用 5 d,对实验性感染 MG的鸡具有显著的保护作用 ,与感染对照组的死亡率 (2 5 %)差异显著 (P<0 .0 1)。氟甲砜霉素及对照药物的增重效果显著高于感染对照组 (P<0 .0 1) ,中、高剂量组还能显著减少气囊损伤率 (P<0 .0 1) ,但氟甲砜霉素各用药组都不能减少抗体反应的阳性率。The minimal inhibitory concentrations(MIC S) of florfenicol and enrofloxacin against Mycoplasma gallisepticum(MG) were determined by two-fold dilution,the MIC of florfenicol and enrofloxacin were respectively 1.25, 0.019 5 mg/L.The in vivo test showed that florfenicol given respectively at 300,400 and 500 mg/kg in feed additive for 5 successive days exhibited significantly protection in broiler chicken infected with MG but mortality of untreated group was 25%(P<0.01).The weight gain of groups treated with florfenicol and enrofloxacin were significantly higher than that of the positive control(P<0.01).The groups treated with a dosage of 400-500 mg/kg of florfenicol reduced significantly air sac lesions scores(P<0.01).However,all groups treated with florfenicol did not reduce the positive serum agglutination reaction,in contrast to the positive group.

关 键 词：药效学 氟甲砜霉素 禽败血支原体 肺炎 

分 类 号：S859.796[农业科学—临床兽医学] S85[农业科学—兽医学]