10,11-二氢-5H-二苯并[b,f]氮杂的合成  

Synthesis of 10,11-Dihydro-5H-dibenzo[b,f]azepine

作　　者：王纪康[1] 王桂林[1] 严巍[1] 钱捷[1] 

机构地区：[1]浙江工业大学化工学院,浙江杭州310014

出　　处：《中国医药工业杂志》2002年第11期525-526,共2页Chinese Journal of Pharmaceuticals

摘　　要：以邻硝基甲苯为起始原料 ,经缩合、加氢还原、磷酸成盐得 2 ,2′-二氨基联苄二磷酸盐 ,再经环合制得 10 ,11-二氢 - 5 H -二苯并 [b,f]氮杂。总收率 6 3.5 %。Dihydro 5 H dibenzo[b,f]azepine was synthesized by using o nitrotolene as starting material which produced 2,2′ diaminobibenzyldiphosphate by condensation, hydrogenation reduction, salification and then ring closure reaction with an overall yield of 63.5%.

关 键 词：2 2'-二氨基联苄二磷酸盐 10 11-二氢-5H-二苯并[b f]氮杂Zhuo 催化加氢 合成 中间体 

分 类 号：R971[医药卫生—药品] TQ460.6[医药卫生—药学]