心房肽类物质对大鼠心肌和豚鼠工作心脏功能的影响  

EFFECTS OF ATRIAL PEPTIDES ON GUINEA PIG WORKING HEART AND MYOCARDIAL PROPERTIES OF RATS

作　　者：杜冠华[1] 田春林[1] 王垣芳[1] 张树平[1] 李治淮[1] 吕世杰[1] 陈树儒 

机构地区：[1]滨州医学院药理学教研室 [2]滨州医学院淄博市医科所

出　　处：《滨州医学院学报》1992年第2期97-100,189,共4页Journal of Binzhou Medical University

摘　　要：作者研究了猪心房肽类提取物对豚鼠和大鼠离体心脏的作用。结果表明,心房肽类物质可使豚鼠工作心脏LVP升高(P<0.05),左室内压微分±dp/dt max也相应增加(P<0.05);心率有所降低(P<0.05)。而心输出量,主动脉流量和冠脉流量无明显变化。在5～150×10^(-4)mg/L浓度下,可使大鼠左心房功能性不应期延长,兴奋性降低,右心房自律性降低。对左房收缩性无显著影响。The effects of atrial peptides on guinea pig working heart and atria of rat in vitro were studied.The results showed that atrial peptides enhanced the LVP,±dP/ dt_(max) and reduced its automaticity in guinea pig working hearts,but had no significant ef- fects on the cardiac output.Atrial peptides prolonged the functional refractory pe iod and lowered excitability in isolated left atria of rats and lowered the automaticity in so- lated right atria of rats.All of these results suggest that these atrial peptides prepara- tions may have autiarrhythmic effects.

关 键 词：心房肽 工作心脏 心肌功能 

分 类 号：R972[医药卫生—药品]