丹参联合缺血预适应对缺血性心肌损伤的保护作用  

Salvia Miltiorrhiza Enhances the Cardioprotective Effects of Ischemic Preconditioning in the Rat

作　　者：梁国庆[1] 孙霞[1] 亢晓冬[1] 缪利英[1] 汪传英[1] 

机构地区：[1]杭州医学高等专科学校生理学教研室,杭州310012

出　　处：《中国现代应用药学》2002年第5期370-372,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :研究丹参 (SM)联合缺血预适应 (IP)对缺血性心肌损伤的保护作用 .方法 :以整体麻醉SD大鼠心脏冠状动脉左前降支结扎 /松开作为缺血 /再灌注动物模型 ,观察对心律失常程度和心肌梗塞范围的影响。结果 :IP能减轻复灌性心律失常的严重程度 ,缩小心肌梗塞范围 ;SM能缩小心肌梗塞范围 ;SM联合IP与单纯IP比较 ,心肌梗塞范围进一步缩小 ;SM联合IP与单纯SM比较 ,心律失常严重程度和心肌梗塞面积均进一步减小。结论OBJECTIVE:To investigate the effect of salvia miltiorrhiza (SM) on the cardioprotection of ischemic preconditioning (IP) in the anaesthetized rat. METHOD:Sprague-Dawley rats were used. The left anterior descending artery was ligated as ischemia. Reperfusion induced arrhythmias and infarct size were measured. RESULTS:IP reduced the severity of reperfusion-induced arrhythmias and limited the infarct size and SM limited the infarct size. SM plus IP significantly reduced the infarct size compared with IP that was used alone and significantly decreased both the infarct size and the severity of reperfusion-induced arrhythmias when compared with SM alone.CONCLUSION:The results suggest that SM will enhance the cardioprotective effects of IP.

关 键 词：丹参 缺血预适应 缺血性心肌损伤 保护作用 

分 类 号：R282.71[医药卫生—中药学]