新型杀精子剂SM-3对人精子超微结构的影响  

Effects of the Spermicidal Agent SM-3 on the Ultrastructure of Human Sperm

作　　者：刘玉环[1] 吕加国[2] 赵亚南[1] 盛毅[1] 王锡智[1] 纪亚忠[1] 

机构地区：[1]第二军医大学长海医院妇产科,上海200433 [2]第二军医大学药学院,上海200433

出　　处：《生殖与避孕》2002年第5期306-307,I004,共3页Reproduction and Contraception

基　　金：国家计划生育委员会;上海市人口与计划生育委员会;总后卫生部资助项目

摘　　要：目的:探讨SM-3杀精、抗生育作用机理。方法:用透射电镜观察SM-3对体外人精子超微结构的影响。结果:SM-3引起精子顶体区质膜肿胀、破溃、顶体酶流失,线粒体空泡样变性。结论:SM-3主要破坏精子顶体及线粒体,从而达到杀精、避孕目的。Objective: To study the spermicidal mechanism of SM-3. Methods:Effects of the spermicidal agent SM-3 on the ultrastructure of human sperm in vitro were studied by using transmission electron microscope. Results:The medicine caused the acrosomal membrane swollen and ruptured and thus sent the acr-some ran off and made the mitochondria vacuolar degeneration. Conclusion:SM-3 can destroy the acrosomal membrane, acrosome, and mitochondria of the sperm to achieve spermicidal and contraceptive effects.

关 键 词：杀精子剂 精子 阴道避孕 超微结构 

分 类 号：R965[医药卫生—药理学]