痰咳宁片祛痰作用的拆方研究  

Expectorant Effect of Tankening Ttablets and Analysis of the Prescription

作　　者：沈文会[1] 谢强敏[1] 吴康松[1] 郑行[1] 

机构地区：[1]浙江大学医学院国家药品监督管理局浙江呼吸药物研究实验室,杭州310031

出　　处：《中药新药与临床药理》2002年第6期371-373,共3页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的通过初步拆方研究评价痰咳宁片配伍的合理性。方法比较痰咳宁组(痰咳宁片)、无麻组(不含麻黄碱的痰咳宁片)和麻黄碱组3组,对小鼠气道酚红排泄和青蛙食道纤毛运动的影响。结果痰咳宁组、无麻组、麻黄碱组均能增强小鼠气道酚红排泄量,加快青蛙食道纤毛运动的速度,但痰咳宁组的作用强度明显优于无麻组或麻黄碱组。结论麻黄碱与中药成分具有协同作用。Objective: To evaluate the rationality of the prescription of Tankening tablets(TKN). Methods:Mice and frogs were allocated to three groups: TKN group, non-ephedrine group( TKN with ephedrine rejected) and ephedrine group. Effects on the tracheal phenol red secretion in mice and the esophageal mucociliary movement in frogs were observed in the three groups. Results:Tracheal phenol red secretion and mucociliary movement were both increased in the three groups and the effect of TKN was more potent than that of ephedrine or TKN with ephedrine rejected. Conclusion:Ephedrine has a synergistic action with the other herbal medicine of TKN.

关 键 词：痰咳宁片 祛痰 药理学 麻黄碱 协同作用 配伍 

分 类 号：R285.6[医药卫生—中药学] R289.[医药卫生—中医学]