血浆中一氧化氮及内皮素含量与大鼠弥漫性脑损伤关系的研究  

Study of the Relation of Plasma Nitric Oxide and Endothelin Concentration With Rat Diffuse Brain Injury

作　　者：王江飞[1] 欧绍武[1] 刘薇[1] 王运杰[1] 

机构地区：[1]中国医科大学第一临床学院神经外科

出　　处：《中国医科大学学报》2002年第5期347-348,351,共3页Journal of China Medical University

摘　　要：目的 :观察大鼠弥漫性脑损伤后血浆中一氧化氮 (NO)及内皮素 (ET 1)含量的变化。方法 :利用Mar marou创立的模型造成大鼠不同程度的弥漫性脑损伤 ,于伤后 6h抽血检测血浆中NO及ET 1含量。结果 :轻、重度弥漫性脑损伤后血浆中NO及ET 1均有明显升高 ,(P <0 .0 5 )。其中轻度损伤后血浆中NO含量从 (2 6 .70±3.30 ) μmol/L升高至 (35 .6 8± 2 .39) μmol/L ,ET 1含量从 (85 .0 7± 2 .89)ng/L升高至 (94 .2 0± 3.4 6 )ng/L。重度弥漫性脑损伤后血浆中NO含量升高至 (46 .86± 4 .1) μmol/L ,ET 1含量升高至 (131.0 4± 9.0 )ng/L。 结论 :NO和ET 1参与弥漫性脑损伤的原发及继发性神经组织损伤的病理过程 ,且二者的血浆浓度与脑损伤程度密切相关。Objective: Our aim was to observe the change of plasma nitric oxide (NO) and endothelin (ET) in rats after diffuse brain injury. Methods: Two groups of rats received mild and heavy diffuse brain injury separately by using the model established by Marmarou A. Six hours after injury, the concerntrations of NO and ET were measured. Results: The concerntrations of NO and ET increased obviously after injury. The concerntration of NO increaed from (26.70± 3.30) μmol/L to (35.68±2.39) μmol/L after mild injury and to (46.86±4.1) μmol/L after heavy injury. The concerntration of ET increased from (85.07±2.89) ng/L to (94.20±3.46) ng/L after mild injury and to (131.04±9.0) ng/L after heavy injury. Conclusion: Both ET and NO take part in the pathophysiologic process of diffuse brain injury, the increased degree of NO and ET is related with the injury degree.

关 键 词：弥漫性脑损伤 一氧化氮 内皮素 大鼠 

分 类 号：R651.15[医药卫生—外科学]