腹膜表面层和腹膜通透性的关系  

Peritoneal surface layer and its relationship with the peritoneal membrane permeability

作　　者：汪涛[1] 

机构地区：[1]北京大学第一医院肾脏内科肾脏病研究所,北京100034

出　　处：《北京大学学报（医学版）》2002年第5期471-473,共3页Journal of Peking University:Health Sciences

基　　金：国家自然科学基金 ( 3 0 0 0 0 81;3 9940 0 13 )资助

摘　　要：Increase in peritoneal membrane permeabil ity is not uncommon in long-t erm peritoneal dialysis patients. It has been shown that increased peritoneal me mbrane permeability is associated with increased mortality in this patient popul ation. We have been thus focused on the pathogenesis of the abnormal peritoneal membrane permeability. It was hypothesized that increased membrane permeability might be due to (1)neoangiogenesis; (2)chronic inflammation; (3)increased hydrau lic permeability of the peritoneal membrane. We have, however, found that increa se d membrane hydraulic permeability may be the key mechanism. We found that the pe ritoneal surface layer, the key component that determines the tissue hydraulic p ermeability, was rich in hyaluronan, phospholipids and surfactant proteins. Dama ging the peritoneal surface layer by shaking the peritoneal cavity, washing, add ing pentobarbital or deoxycholic acid or hyaluronidase or phospholipidase, we ha ve sig nificantly increased the membrane permeability. On the contrary, by adding hyalu r onan, phospholipids or steroid to increase the formation of the peritoneal surfa ce layer, we have decreased significantly the peritoneal permeability. Our resea rch work on this issue has been well recognized and appreciated by the interna tional society.Increase in peritoneal membrane permeabil ity is not uncommon in long-t erm peritoneal dialysis patients. It has been shown that increased peritoneal me mbrane permeability is associated with increased mortality in this patient popul ation. We have been thus focused on the pathogenesis of the abnormal peritoneal membrane permeability. It was hypothesized that increased membrane permeability might be due to (1)neoangiogenesis; (2)chronic inflammation; (3)increased hydrau lic permeability of the peritoneal membrane. We have, however, found that increa se d membrane hydraulic permeability may be the key mechanism. We found that the pe ritoneal surface layer, the key component that determines the tissue hydraulic p ermeability, was rich in hyaluronan, phospholipids and surfactant proteins. Dama ging the peritoneal surface layer by shaking the peritoneal cavity, washing, add ing pentobarbital or deoxycholic acid or hyaluronidase or phospholipidase, we ha ve sig nificantly increased the membrane permeability. On the contrary, by adding hyalu r onan, phospholipids or steroid to increase the formation of the peritoneal surfa ce layer, we have decreased significantly the peritoneal permeability. Our resea rch work on this issue has been well recognized and appreciated by the interna tional society.

关 键 词：腹膜 腹膜透析 膜通透性 透明质酸 表面层 

分 类 号：R459.5[医药卫生—治疗学]