金属硫蛋白——心血管细胞保护剂  

Metallothionein- cardiovascular cytoprotective agent

作　　者：杨靖辉[1] 常林[1] 唐朝枢[1] 

机构地区：[1]北京大学基础医学院生理学系,北京100083

出　　处：《北京大学学报（医学版）》2002年第5期482-487,共6页Journal of Peking University:Health Sciences

基　　金：国家自然科学基金 ( 3 9970 2 95 );国家重点基础研究发展规划项目 ( 973 )基金 (G2 0 0 0 0 5 690 5 )资助

摘　　要：金属硫蛋白 (MT)是一类富含半胱氨酸的小分子非酶蛋白 ,在生物界中广泛存在 ,具有重金属解毒、清除氧自由基、稳定生物膜等多种生物学功能。其合成可被多种因素诱导 ,在炎症、感染、休克、组织损伤等病理状态下表达增加。近年来对MT转基因动物的研究发现 ,MT是一种强的内源性细胞保护物质 ,在心血管系统抗损伤保护中发挥着重要的作用。Metallothionein (MT) is a low molecular weight no n-enzyme protein rich in L -cysteine. It widely distributes in various animal and plant species a nd pla ys important roles in detoxifying against harmful heavy metals, scavenging oxyen free radicals and stabilizing biomembranes. MT synthesis can be easily induced b y many factors. MT expression is up-regulated in stress and pathologic conditio n s such as inflammation, infection, shock, and tissue injury etc. In recent years , accumulating experiments with transgenic and gene knockout animal models have showed that MT is a kind of strong endogenous cytoprotective agent which plays importa nt roles in protecting against cardiovascular injury. Exogenous administration w ith MT or induced endogenous MT production may be used as a new strategy in prevent ion and therapy of cardiovascular diseases.

关 键 词：金属硫蛋白 药理学 细胞 药物作用 心血管疾病 预防 控制 

分 类 号：R972[医药卫生—药品]