辽宁省成人血清甲状腺球蛋白正常值范围探讨  

Study on the normal range of adult serum thyroglobulin in Liaoning Province

作　　者：孙蕾[1] 王健辉[1] 苏孟[2] 杨园园[3] 高嵘[1] Sun Lei;Wang Jianhui;Su Meng;Yang Yuanyuan;Gao Rong(Department for Endemic Disease Prevention and Control,Center for Disease Prevention and Control of Liaoning Province,Shenyang 110005,China;Department for Endemic Disease Prevention and Control,Center for Disease Prevention and Control of Shenyang City,Shenyang 110037,China;Department for Endemic Disease Prevention and Control,Center for Disease Prevention and Control of Yingkou City,Yingkou 115200,China)

机构地区：[1]辽宁省疾病预防控制中心地方病防制所,沈阳110005 [2]沈阳市疾病预防控制中心地方病科,110037 [3]辽宁省营口市疾病预防控制中心地方病科,115200

出　　处：《中华地方病学杂志》2019年第7期527-529,共3页Chinese Journal of Endemiology

基　　金：辽宁省自然科学基金(20170540490)

摘　　要：目的探讨辽宁省成人血清甲状腺球蛋白(Tg)正常值范围。方法2017年2-11月,在沈阳康平县(内陆组)和营口盖州市(沿海组),按照整群分层抽样方法调查不同年龄段成人Tg水平。将成人分为青年(18-44岁)、中年(45-59岁)、老年(≥60岁)组,采集空腹血样。采用全自动电化学发光免疫分析仪测定Tg,甲状腺功能指标[促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)],甲状腺球蛋白抗体(TgAb)和甲状腺过氧化物酶抗体(TPOAb)水平。对甲状腺功能正常和抗体阴性成人Tg测定值进行统计分析,应用百分位数法计算双侧95%正常值范围,即P2.5-P97.5。结果共纳入成人685人,Tg水平为9.86μg/L,其中内陆组333人,Tg水平为8.97μg/L;沿海组352人,Tg水平为10.44μg/L。男性255人,女性430人,Tg水平分别为9.39、9.99μg/L。青、中、老年组各179、307、199人,Tg水平分别为8.84、9.22、11.73μg/L,组间比较差异有统计学意义(H=9.607,P<0.05)。成人Tg正常值范围为1.23-58.63μg/L,青、中、老年组Tg正常值范围分别为1.62-41.90、0.99-54.58、0.94-85.78μg/L。结论成功建立了辽宁省成人血清Tg正常值范围。ObjectiveTo deduce the normal range of thyroglobulin(Tg)of adults senum in Liaoning Province.MethodsFrom February to November 2017,in Kangping County of Shenyang(inland group)and Gaizhou City of Yingkou(coastal group),the Tg levels of adults in different age groups were investigated according to the cluster stratified sampling method.Adults were divided into young(18-44 years old),middle(45-59 years old),and elderly(≥60 years old)groups,and fasting blood samples were collected.Levels of Tg,thyroid function[thyroid stimulating hormone(TSH),free triiodothylaminogenic acid(FT3),free thyroxine(FT4)],thyroglobulin antibody(TgAb)and thyroid peroxidase antibody(TPOAb)were determined by automatic electrochemiluminescence immunoassay analyzer.Statistical analysis was performed on Tg measured values of normal thyroid function and antibody-negative adults,and the percentile range(P2.5-P97.5)was used to calculate the 95%normal range of both sides.ResultsA total of 685 adults were included,with a Tg level of 9.86μg/L,including 333 adults in the inland group with a Tg level of 8.97μg/L,and 352 adults in the coastal group with a Tg level of 10.44μg/L.There were 255 males and 430 females,Tg levels were 9.39 and 9.99μg/L,respectively.There were 179,307 and 199 adults in the young,middle and elderly groups,Tg levels were 8.84,9.22,and 11.73μg/L,respectively,the differences were statistically significant(H=9.607,P<0.05).The normal range of Tg in adults was 1.23-58.63μg/L,and the normal ranges of Tg in the young,middle and elderly groups were 1.62-41.90,0.99-54.58,and 0.94-85.78μg/L,respectively.ConclusionSuccessful establishment of the normal range of adults serum Tg in Liaoning Province.

关 键 词：甲状腺球蛋白 参考值 成人 

分 类 号：R58[医药卫生—内分泌]