碘化甲状腺球蛋白与自身免疫性甲状腺炎  

Iodinated thyroglobulin and autoimmune thyroiditis

作　　者：王晴钰 盛斯涵 李俊瑾 姚小梅[1] Wang Qingyu;Sheng Sihan;Li Jury in;Yao Xiaomei(Department of Physiology and Pathophysiology,Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津医科大学生理学与病理生理学系,300070

出　　处：《中华地方病学杂志》2019年第7期582-585,共4页Chinese Journal of Endemiology

基　　金：国家自然科学基金(81874257);天津市自然科学基金(16JCYBJC26100)

摘　　要：碘化甲状腺球蛋白(TG)可反映甲状腺激素和甲状腺中碘的存储情况,对甲状腺功能有着重要影响,但目前碘化TG与自身免疫性甲状腺炎的研究尚有待深入。作者综述了碘化TG的形成、测定方法,碘化TG作用的分子机制,包括与甲状腺过氧化物酶调节、促甲状腺激素受体表达、甲状腺转录因子1和双链复合蛋白8表达及钠碘转运体表达的关系,探讨高碘化TG诱导自身免疫性甲状腺炎的免疫和自噬机制。Iodinated thyroglobulin(TG)can reflect the storage of thyroid hormones and iodine in the thyroid,which has an important influence on thyroid function.However,the study on iodinated TG and autoimmune thyroiditis has yet to be further conducted.This paper reviews the formation of iodinated TG,the measuring method of TG,and the molecular mechanism of iodinated TG function,including the relationships between iodinated TG and thyroid peroxidase adjustment,the expression of thyrotropin receptor,thyroid transcription factor 1,paired box gene 8,and iodine and sodium transporter,last but not least,we aim to investigate the immune and autophagy mechanisms of high iodinated TG-induced autoimmune thyroiditis.

关 键 词：碘 甲状腺球蛋白 碘化甲状腺球蛋白 自身免疫性甲状腺炎 

分 类 号：R58[医药卫生—内分泌]