曲安萘德联合丹参酮液治疗软腭黏膜下纤维性变的疗效评价  

Efficacy for combined injection of salvizanolic acid B with triamcinolone acetonide on the treatment of the soft palate with oral submucous fibrosis

作　　者：陆璨[1] 翦新春[1,2,3] LU Can;JIAN Xinchun(Department of Oral and Maxillofacial Surgery,Xiangya Hospital,Central South University;Institute of Oral Precancerous Lesions,Central South University;Kaifu Zhenya Clinic of Stomatology,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院口腔医学中心口腔颌面外科 [2]中南大学口腔癌前病变研究所 [3]长沙市开福振亚口腔医学部,长沙410008

出　　处：《中南大学学报（医学版）》2019年第7期801-804,共4页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(81260166,81041052,30572044)~~

摘　　要：目的:评价曲安萘德联合丹参酮液注射治疗软腭黏膜下纤维性变的疗效。方法:对33例中期和后期口腔黏膜下纤维性变患者的软腭黏膜下分别注射曲安萘德和丹参酮液各1.5 mL,每周1次,10次为1疗程,共3个疗程,每个疗程间隔30 d。3个疗程后的第12,24和36个月,对患者的软腭黏膜由灰白变红色及毛细血管增生的数量按Ⅰ-Ⅳ级进行疗效评价。结果:33例患者完成了3个疗程的治疗和24个月的随访;31例患者完成了36个月的随访且疗效明显好于第12个月(P=0.004)。所有患者治疗中及治疗后未出现特殊不良反应。结论:曲安萘德联合丹参酮液注射治疗软腭黏膜下纤维性变的疗效满意。Objective:To evaluate therapeutic effect of combined injection of salvizanolic acid B with triamcinolone acetonide on the treatment of the soft palate with oral submucous fibrosis.Methods:Salvizanolic acid B combined with triamcinolone acetonide was consecutively applied once a week for 30 weeks for 33 patients with middle and later periods of oral submucous fibrosis.The response rate of color change in the soft palate and the increase of capillary vessels(determined by degreeⅠ-Ⅳvisual analog scale)were evaluated at the 12th,24th,and 36th months after 30 weeks treatment.Results:Thirty-three patients were fulfilled the study without obvious adverse reactions and they were followed up for 24 months,while 31 patients were followed up for 36 months.The color change in the soft palatal mucus and the increase of capillary vessels at the 36th month follow-up after treatment were significantly better than those at the 12th month(P=0.004).Conclusion:Combined injection of salvizanolic acid B with triamcinolone acetonide in the treatment of the soft palate with oral submucous fibrosis is effective.

关 键 词：曲安萘德 丹参酮液 软腭 口腔黏膜下纤维性变 

分 类 号：R28[医药卫生—中药学]