海南龙血树人工血竭与天然血竭的抗炎镇痛活性比较  

Comparison of Analgesic and Anti-inflammatory Activities Between Natural and Artificially Induced Dragon’s Blood of Dracaena cambodiana

作　　者：王辉[1] 杨宁 吴晓鹏[1] 戴好富[1] 梅文莉[1] WANG Hui;YANG Ning;WU Xiaopeng;DAI Haofu;MEI Wenli(Ministry of Agriculture and Rural Affairs Key laboratory for Biology and Genetic Resources of Tropical Crops/Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou,Hainan 571001,China,Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine,Haikou,Hainan 571001,China)

机构地区：[1]中国热带农业科学院热带生物技术研究所/农业部热带作物生物学与遗传资源利用重点实验室/海南省黎药资源天然产物研究与利用重点实验室

出　　处：《热带生物学报》2019年第2期159-164,共6页Journal of Tropical Biology

基　　金：海南省自然科学基金创新研究团队项目(2017CXTD020);国家自然科学基金项目(31400297);中国热带农业科学院院级创新团队南药产业技术创新团队项目(17CXTD-15)

摘　　要：为了探讨人工诱导海南龙血树(Dracaena cambodiana Pierre ex Gagnep.)所产血竭是否具有抗炎镇痛活性,笔者分别采用小鼠扭体反应模型、小鼠耳廓肿胀模型和醋酸致小鼠腹腔毛细血管通透性模型对海南龙血树人工血竭和天然血竭的镇痛活性及抗炎活性做了比较。结果表明:海南龙血树人工诱导血竭可显著延长醋酸所致的小鼠扭体反应潜伏期,镇痛活性优于天然血竭;海南龙血树人工血竭和天然血竭均可显著抑制二甲苯所致的小鼠耳廓肿胀,两者具有类似的抗炎镇痛活性。To evaluate analgesic and anti-inflammatory activities of artificially induced dragon’s blood of Dracaena cambodiana,the natural and artificially induced dragon’s bloods were evaluated and compared in terms of analgesic and anti-inflammatory activities by using the writhing model in mice, the mouse auricle swelling model and the capillary permeability in abdominal cavity of mice. Artificially induced dragon’s blood of D. cambodiana significantly increased the latency of mouse writhing induced by acetic acid, indicating that it had a higher analgesic activity than natural one. Both natural and artificially induced dragon’s blood markedly reduced auricle swelling caused by dimethylbenzene in mice, suggesting their similarity in anti-inflammatory activity. Artificially induced dragon’s blood of D. cambodiana had similar analgesic and anti-inflammatory activities with natural dragon’s blood.

关 键 词：人工诱导血竭 海南龙血树 天然血竭 抗炎 镇痛 

分 类 号：R285.5[医药卫生—中药学]