滋阴降火方对高血压病早期肾损害的疗效及尿微量蛋白的研究  

Curative Effects of Ziyin Jianghuo Prescription on Early Renal Damage in Hypertension and Study on Urine Microprotein

作　　者：王梦楠 杜敏 宋舜尧 陈国华[2] Wang Mengnan;Du Min;Song Shunyao;Chen Guohua(Weifang Medical College,Weifang 261042,China;Weifang People′s Hospital,Weifang 261042,China)

机构地区：[1]潍坊医学院,潍坊261042 [2]山东省潍坊市人民医院,潍坊261000

出　　处：《世界中医药》2019年第7期1753-1756,1761,共5页World Chinese Medicine

基　　金：潍坊市卫生计生委科研计划项目(wfwsjs_2018_0038)

摘　　要：目的:探究滋阴降火方对高血压病早期肾损害的疗效及尿微量蛋白的影响。方法:选取2015年8月至2018年1月潍坊市人民医院收治的高血压病早期肾损害患者178例作为研究对象,按照随机数字表法分为对照组和观察组,每组89例。对照组采用常规综合治疗,观察组在对照组的基础上加用滋阴降火中药。2组患者均连续治疗1个月后观察疗效,检测肾功能以及肾段动脉血流动力学数值。结果:治疗后,观察组的总有效率为87.60%,明显高于对照组的总有效率60.70%(P<0.05)。治疗后,对照组和观察组的BUN、SCr、尿液β2-微球蛋白(β2-MG)、尿液微量白蛋白(mAIb)指标较治疗前明显下降,且观察组治疗后BUN、SCr、β2-MG、mAIb指标低于对照组(P<0.05)。治疗后,对照组和观察组的PSV、EDV均较治疗前明显上升,观察组治疗后PSV、EDV高于对照组;对照组和观察组的RI均较治疗前明显下降,观察组治疗后RI低于对照组(P<0.05)。结论:滋阴降火方对高血压病早期肾损害患者具有较好的疗效,可以显著改善肾段血流,提高患者的肾功能,降低尿蛋白含量,值得临床推广应用。Objective:To explore the curative effects of Ziyin Jianghuo Prescription on early renal damage in hypertension and study on urine microprotein.Methods:A total of 178 hypertensive patients with early renal damage in Weifang People′s Hospital from August 2015 to January 2018 were selected and randomly divided into a control group and an observation group according to random number table,with 89 cases in each group.The control group was treated with general comprehensive treatment,while the observation group was treated with traditional Chinese medicine Ziyin Jianghuo Prescription on the basis of the comprehensive treatment group.After one month of continuous treatment,the curative effect was observed.The indexes of renal function and renal segmental artery hemodynamics were measured and compared between the 2 groups.Results:After treatment,the total effective rate in the observation group was 87.60%,which was significantly higher than that in the control group(60.70%)(P<0.05).After treatment,the indexes of renal function(BUN,SCr,β2-microglobulin(β2-MG),urine microalbumin(mAIb))in the control group and the observation group were significantly decreased than those before treatment,while those in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of PSV and EDV in the control group and the observation group were significantly increased than those before treatment.After treatment,the levels of PSV and EDV in the observation group were higher than those in the control group.The level of RI in the control group and the observation group were significantly decreased than those before treatment,and the level of RI in the observation group was lower than that in the control group(P<0.05).Conclusion:Ziyin Jianghuo Prescription has a good effect on patients with early renal damage in hypertension,It can significantly improve renal segmental blood flow and improve renal function.reduce urinary protein content,which is worthy of clinical application.

关 键 词：滋阴降火方 高血压病早期肾损害 疗效 肾功能 尿微量蛋白 

分 类 号：R255.3[医药卫生—中医内科学]