葛根素注射液联合丹参酮ⅡA磺酸钠治疗慢性充血性心力衰竭患者的疗效及对血浆血浆肾素活性和醛固酮的影响  

Effects of Puerarin Injection Combined with Sodium Tanshinone Ⅱ A Sulfonate on Chronic Congestive Heart Failure Patients and Their Influence on Plasma PRA and ALD

作　　者：曾胜煌 何长国 王越 罗玉环 Zeng Shenghuang;He Changguo;Wang Yue;Luo Yuhuan(Second Department of Heart Disease,Lu′an Traditional Chinese Medicine Hospital,Lu′an 237000,China)

机构地区：[1]安徽省六安市中医院心病二科

出　　处：《世界中医药》2019年第7期1809-1812,共4页World Chinese Medicine

基　　金：安徽省卫生厅中医药科研项目(2015ZY05)

摘　　要：目的:探讨葛根素注射液联合丹参酮ⅡA磺酸钠治疗慢性充血性心力衰竭(CHF)患者的疗效及对血浆肾素活性(PRA)和醛固酮(ALD)的影响。方法:选取2015年2月至2017年9月六安市中医院收治的CHF患者90例作为研究对象,按照随机数字表法分为对照组和观察组,每组45例。对照组患者接受西医联合丹参酮ⅡA磺酸钠治疗,观察组患者在对照组基础上加入葛根素注射液治疗,均持续30 d。比较2组治疗后近期疗效、心功能及血浆PRA、醛固酮水平的差异。结果:治疗后,观察组患者治疗有效率高于对照组患者;心功能指标心排出量(CO)、左室射血分数(LVEF)高于对照组患者,左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)低于对照组患者;血浆PRA、醛固酮低于对照组患者,差异均有统计学意义(P<0.05)。结论:在西医以及丹参酮ⅡA磺酸钠治疗同时加入葛根素注射液联合治疗CHF患者,可进一步提升患者的近期疗效,改善心功能和机体神经内分泌状态。Objective:To investigate the effects of Puerarin Injection combined with Sodium tanshinone Ⅱ A sulfonate on chronic congestive heart failure(CHF)patients and their influence on plasma PRA and ALD.Methods:According to the random number table method,90 cases of CHF patients admitted in Lu′an Traditional Chinese Medicine Hospital from February 2015 to September 2017 were divided into a control group(n=45)and an observation group(n=45).Patients in the control group were treated with western medicine combined with Sodium tanshinone Ⅱ A sulfonate,while those in the observation group were treated with Puerarin Injection on the basis of the control group,both lasted for 30 d.The difference in short-term curative effect,level of cardiac function indexes and plasma PRA,ALD between the 2 groups were compared.Results:Thirty days after treatment,total effective rate in the observation group was higher than that in the control group;and levels of cardiac function indexes such as CO,LVEF were higher than those in the control group.Levels of LVEDD,LVESD in the observation group were lower than those in the control group;plasma PRA and ALD levels in the observation group were lower than those in the control group,and the differences of above indexes were statistically significant(P<0.05).Conclusion:Combination of Puerarin Injection basing on western medicine and Sodium tanshinone Ⅱ A sulfonate,can further improve CHF patients short-term curative effect,actively change the heart function and coordinate the state of the body′s neuroendocrine.

关 键 词：慢性充血性心力衰竭 葛根素注射液 常规治疗 丹参酮ⅡA磺酸钠 肾素活性 血浆 醛固酮 心功能 临床疗效 

分 类 号：R283[医药卫生—中药学] R541.4[医药卫生—中医学]