滋肾疏肝法对特发性中枢性性早熟女童第二性征及生长发育的影响  

Effects of Nourishing Kidney and Soothing Liver Method on Secondary Sexual Characteristics and Growing Development of Girls with Idiopathic Central Precocious Puberty

作　　者：张淼[1] 柳静[1] 潘宇琛[1] 刘慧丽[1] Zhang Miao;Liu Jing;Pan Yuchen;Liu Huili(Department of Traditional Chinese Medicine,Beijing Children′s Hospital Affiliated to Capital Medical University,Beijing 100045,China)

机构地区：[1]首都医科大学附属北京儿童医院中医科

出　　处：《世界中医药》2019年第7期1825-1827,1831,共4页World Chinese Medicine

基　　金：北京中医药科技发展资金项目(QN2015-20)

摘　　要：目的:研究滋肾疏肝法对特发性中枢性性早熟(ICCP)女童第二性征的临床症状和体征、生长发育的影响。方法:选取2015年6月至2017年6月首都医科大学附属北京儿童医院收治的ICCP患儿88例作为研究对象,按照随机数字法分为对照组和观察组,每组44例,对照组予大补阴丸,观察组在对照组基础上应用滋肾疏肝法治疗。比较2组患者治疗后的临床疗效,比较2组患者治疗前后卵巢、子宫容积、骨龄提前变化及性激素水平。结果:治疗后观察组总有效率高达95.5%,显著高于对照组的72.7%;治疗后2组FSH、LH、E 2水平均明显降低(P<0.01),且观察组明显低于对照组(P<0.01);治疗后2组卵巢及子宫容积均显著缩小(P<0.01),且观察组明显低于对照组(P<0.01);治疗后2组骨龄提前均明显减少(P<0.01),且观察组明显低于对照组(P<0.01)。结论:滋阴疏肝法可以明显提高ICCP女童临床治疗效果,降低血清性激素水平,减小卵巢、子宫容积和骨龄提前变化,安全性高。Objective:To study the effects of nourishing kidney and soothing liver method on the clinical symptoms,signs and growth of secondary sexual symptoms in girls with idiopathic central precocious puberty(ICCP).Methods:A total of 88 ICCP girls admitted to Beijing Children′s Hospital Affiliated to Capital Medical University from June 2015 to June 2017 were randomly divided into a control group(n=44)and an observation group(n=44).The control group was given Dabuyin Pill.The observation group was treated with nourishing kidney and soothing liver method on the basis of the control group.The clinical efficacy of the 2 groups after treatment was compared.The ovarian and uterine volume,bone age and sex hormone levels of the 2 groups before and after treatment were compared.Results:After treatment,the total effective rate of the observation group was 95.5%,which was significantly higher than 72.7%of the control group;after treatment,the levels of FSH,LH and E 2 in the 2 groups were significantly decreased(P<0.01),and the observation group was significantly lower than the control group(P<0.01);after treatment,the ovarian and uterine volumes of the 2 groups were significantly reduced(P<0.01),and the observation group was significantly lower than the control group(P<0.01);after treatment,the bone age of the 2 groups was significantly reduced(P<0.01),and the observation group was significantly lower than that of the control group(P<0.01).Conclusion:The method of nourishing kidney and soothing liver method can significantly improve the clinical therapeutic effect of ICCP girls,reduce the level of serum sex hormones,reduce the volume of ovary,uterus and bone age changes in advance,and has high safety.

关 键 词：滋肾疏肝法 特发性中枢性性早熟 女童 第二性征 生长发育 

分 类 号：R272.6[医药卫生—中医儿科学]