中药联合输卵管造影术治疗输卵管性不孕的临床疗效  

Clinical effect on tubal factor infertility treated with Chinese herbal medicine and salpingography

作　　者：张武平 杨浩 张博华 肖江梅 ZHANG Wu-ping;YANG Hao;ZHANG Bo-hua;XIAO Jiang-mei(Sunsimiao Hospital,Beijing University of Traditional Chinese Medicine,Tongchuan Shaanxi 727000;Department of Radiology of Tongchuan People′s Hospital,Tongchuan Shaanxi 727000;Tongchuan Yintai Municipal Center of Disease Control and Prevention,Tongchuan Shaanxi 727000)

机构地区：[1]北京中医药大学孙思邈医院,陕西铜川727000 [2]铜川市人民医院影像科,陕西铜川727000 [3]铜川市印台疾控中心,陕西铜川727000

出　　处：《世界中西医结合杂志》2019年第7期987-991,共5页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察中药多途径联合X线输卵管造影术治疗输卵管性不孕患者临床疗效及对血清IL-6、ICAM-1影响。方法纳入输卵管性不孕患者184例,采用随机数字表法分为治疗组和对照组各92例。治疗组给予中药多途径辅助治疗+X线输卵管造影术;对照组给予穴位注射+X线输卵管造影术,连续治疗3个月。观察两组妊娠情况、输卵管通畅度和临床疗效,检测血清IL-6、ICAM-1含量。结果治疗后,治疗组宫内妊娠率为56.0%(51/92),对照组妊娠率为39.8%(36/92),两组比较差异有统计学意义(χ^2=4.955,P=0.037);治疗后治疗组通畅度为56.0%(51/92),对照组通畅度为39.8%(36/92%),两组比较差异有统计学意义(Z=-2.847,P=0.035);两组血清IL-6、ICAM-1含量评分均较治疗前降低(P<0.05);治疗后治疗组IL-6(pg/ml)、ICAM-1(μg/L)[(51.05±8.81)pg/ml比(70.24±9.15),t=5.030]、[(165.37±40.28)μg/L比(204.81±36.52)μg/L,t=6.405]均低于对照组(P<0.05);治疗组总有效率为95.65%(88/92),对照组为89.13%(82/92),两组比较差异有统计学意义(Z=-2.783,P=0.005)。结论中药多途径联合X线输卵管造影术治疗输卵管性不孕疗效满意,改善输卵管通畅性、降低血清IL-6、ICAM-1含量,提高妊娠率。Objective To observe the clinical effect on tubal factor infertility(TFI)in the patients after treated with multi-approach of Chinese herbal medicine and X-ray salpingography and the impact on serum IL-6 and ICAM-1.Methods A total of 184 patients with TFI were divided into a treatment group and a control group,92 cases in each one according to random number table.The contraception with condom was used during treatment in the two groups.In the treatment the combined treatment with multi-approach of Chinese herbal medicine and X-ray salpingography was adopted.In the control group,the acupoint injection and X-ray salpingography were combined.The treatment lasted for 3 months.The pregnancy condition,tubal unobstruction and clinical effect were observed in the two groups.The levels of IL-6 and ICAM-1 in serum were determined.Results The uterine pregnancy rate was 56.0%(51/92)in the treatment group and was 39.8%(36/92)in the control group,indicating the significant difference(χ^2=4.955,P=0.037).The unobstructed rate was 56.0%(51/92)in the treatment group and was 39.8%(36/92)in the control group,indicating the significant difference(Z=-2.847,P=0.035).After treatment,the levels of IL-6 and ICAM-1 were reduced as compared with those before treatment in the two groups(P<0.05).After treatment,the results of IL-6(pg/ml)and ICAM-1(μg/L)in the treatment groups were lower than the control group[(51.05±8.81)pg/ml vs(70.24±9.15),t=5.030;165.37±40.28)μg/L vs(204.81±36.52)μg/L,t=6.405](P<0.05).The total effective rate was 95.65%(88/92)in the treatment group and was 89.13%(82/92)in the control group,indicating the significant difference(Z=-2.783,P=0.005).Conclusion The combined treatment with multi-approach of Chinese herbal medicine and X-ray salpingography achieves the satisfactory effect on TFI.This combined therapy removes the tubal obstruction,reduces the levels of serum IL-6 and ICAM-1 and improves the pregnancy rate.

关 键 词：输卵管性不孕 中药多途径 X线输卵管造影术 血清IL-6 ICAM-1 

分 类 号：R271.14[医药卫生—中医妇科学]