德国肉用美利奴羊全基因组选择信号检测  

Genome-wide Detection of Selection Signature in German Merino Mutton Sheep

作　　者：刘佳森 李蕴华 王润元 蒋守军 马万山 王利勇 LIU Jia-sen;LI Yun-hua;WANG Run-yuan;JIANG Shou-jun;MA Wan-shan;WANG Li-yong(Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences,Hohhot 010031,China;Baiyinxile Livestock Farm of Xilin Gol League of Inner Mongolia,Xilinhot 026000,China;Inner Mongolia Demei Stud Sheep Farm for Pure-bred Mutton Sheep,Xilinhot 026000,China)

机构地区：[1]内蒙古自治区农牧业科学院,内蒙古呼和浩特010031 [2]内蒙古自治区锡林郭勒盟白音锡勒牧场,内蒙古锡林浩特026000 [3]内蒙古德美纯种肉羊种羊场,内蒙古锡林浩特026000

出　　处：《畜牧与饲料科学》2019年第7期1-7,共7页Animal Husbandry and Feed Science

基　　金：国家自然科学基金项目（31560624）;内蒙古科技计划项目（201502064）;内蒙古自然科学基金项目（2015MS0381）;内蒙古农牧业科技创新基金项目（2017CXJJM01-3）;内蒙古自治区农牧业科学院青年创新基金项目（2013QNJJM17）

摘　　要：旨在研究德国肉用美利奴羊基因组选择信号。利用绵羊高密度SNPs芯片,运用iHS方法检测德国肉用美利奴羊基因组选择信号,并通过生物信息学分析揭示其潜在受选择基因。选择信号检测结果表明,在全基因组范围内共检测到220个具有选择信号的基因组区段,这些区段内与895个候选基因紧密相关。基因富集结果表明,这些基因主要与蛋白翻译、骨骼发育、生物合成调控、肌肉器官发育、视黄酸受体活性、转录因子结合、核糖体组分等相关。研究结果为充分利用德国肉用美利奴羊的种用价值以及高效开展该品种羊的群体改良工作提供了参考依据。The aim of this study was to assess the genome selection signature in German Merino mutton sheep. The high-density SNPs chip for sheep and iHS method was used to detect the genome selection signature, and the potential selection genes was revealed via bioinformatical analysis. The selection signature detection results indicated that a total of 220 genomic segments with selection signature were found within the genome-wide range. These segments were closely related to 895 candidate genes. Gene enrichment results indicated that these genes were mainly involved in protein translation, skeletal development, biosynthesis regulation, muscle organ development, retinoic acid receptor activity, transcription factor binding and ribosome components. The results obtained in this study provide a reference for making full use of the breeding value of German Merino mutton sheep and efficiently carrying out population improvement work for this breed of sheep.

关 键 词：德国肉用美利奴羊 选择信号 高密度SNPs芯片 

分 类 号：S826.862[农业科学—畜牧学]