基于TiO2NRs@ZnIn2S4NSs复合材料的谷胱甘肽光电化学传感器的构建与应用  

A Novel Glutathione Photoelectrochemical Sensor Based on Titanium Dioxide Nanorods@ZnIn2S4 Nanosheets Nanocomposites

作　　者：唐小强 陈裕雲 罗燕妮 韦富存 杜方凯 谭学才 TANG Xiao-Qiang;CHEN Yu-Yun;LUO Yan-Ni;WEI Fu-Cun;DU Fang-Kai;TAN Xue-Cai(School of Chemistry and Chemical and Engineering,Guangxi University for Nationalities,Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry,Guangxi Key Laboratory of Chemistry and Engineering of Forest Products,Nanning 53008,China)

机构地区：[1]广西民族大学化学化工学院广西高校食品安全与药物分析化学重点实验室广西林产化学与工程重点实验室

出　　处：《分析化学》2019年第8期1188-1194,共7页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.21365004);广西重点研发计划项目(No.桂科AB18126048);广西科技基地和人才专项项目(No.AD18126005);广西高校中青年教师科研基础能力提升项目(No.2019KY0162);广西民族大学研究生教育创新计划(No.gxun-chxps201821)资助~~

摘　　要：采用简便的两步水热原位生长法,以FTO为基底制备了二氧化钛纳米棒(TiO 2 nanorods,TiO 2 NRs)/硫铟锌纳米片(ZnIn 2S 4 nanosheets,ZnIn 2S 4 NSs)复合材料(TiO 2 NRs@ZnIn 2S 4 NSs/FTO),并基于此构建了一种新型谷胱甘肽(GSH)光电化学传感器。分别采用扫描电镜(SEM)、X射线能谱仪(EDX)、X射线粉末衍射仪(XRD)和紫外-可见漫反射吸收光谱(UV-vis DRS)对TiO 2 NRs@ZnIn 2S 4 NSs/FTO复合材料的形貌、结构和性能进行了表征,通过电流-时间法(i-t)和电化学阻抗法(EIS)研究了PEC传感器的性能。结果表明,光电流大小与GSH浓度在1~130μmol/L范围内呈良好的线性关系,相关系数R=0.9919,检出限为0.1μmol/L(S/N=3)。此传感器具有较高的稳定性和良好的选择性及重现性,将其应用于市售的谷胱甘肽片和注射用还原型谷胱甘肽的检测,加标回收率为99%~110%。A binder-free efficient sulphur indium zinc nanosheets coating titanium dioxide nanorods on conductive fluorine-doped tin oxide substrate electrode (TiO 2 NRs@ZnIn 2S 4 NSs/FTO) was developed by simple two-steps hydrothermal method. The morphology, structure and element composition of the as-prepared materials was characterized by scanning electron microscopy, X-ray diffraction, X-ray energy-dispersive spectroscopy and UV-visible diffuse reflectance spectroscopy, respectively. A novel glutathione (GSH) photoelectrochemical (PEC) sensor was fabricated based on TiO 2 NRs@ZnIn 2S 4 NSs/FTO modified electrode. The properties of the PEC sensor were studied via current-time curve ( i-t ) and electrochemical impedance spectroscopy techniques. Under the optimal conditions, GSH concentration in the range of 1-130 μmol/L had a good linear relationship with photocurrent ( R =0.9919), and the detection limit was 0.1 μmol/L ( S/N =3). The fabricated PEC sensor exhibited good selectivity, high stability, and high reproducibility. Moreover, This PEC sensor was successfully applied to detection of GSH in glutathione tablets and reduced GSH for injection samples with favorable recoveries of 99%-110%.

关 键 词：二氧化钛纳米棒 硫铟锌纳米片 光电化学传感器 谷胱甘肽 

分 类 号：R28[医药卫生—中药学]