洋茉莉醛的合成工艺改进  

Improved Synthesis of Piperonal

作　　者：崔新强 李新志 张彬 孔祥雨 于治见 刘文涛 杨利 CUI Xin-qiang;LI Xin-zhi;ZHANG Bin;KONG Xiang-yu;YU Zhi-jian;LIU Wen-tao;YANG Li(Shandong Provincial Key Laboratory of Chemical Drugs,Shandong Academy of Pharmaceutical Science,Jinan 250101,China)

机构地区：[1]山东省药学科学院山东省化药重点实验室

出　　处：《食品与药品》2019年第4期307-308,共2页Food and Drug

摘　　要：目的改进洋茉莉醛的合成工艺。方法以胡椒环、乙醛酸为原料,经缩合、氧化重结晶等反应制得洋茉莉醛。结果洋茉莉醛合成总收率50%,纯度99%。所得产品经熔点、质谱(MS)和核磁共振氢谱(1H NMR)等方法确证。结论改进后的工艺操作简单,适合工业化生产。Objective To improve the synthesis process of piperonal.Methods Starting from 1,3-benzodioxole and glyoxylic acid,piperonal was obtained by condensation,oxidation and recrystallization.Results The total yield was 50%,and the purity was 99%.The structure of the target compound was confirmed by melting point,MS and 1H NMR.Conclusion The improved process is simple and suitable for industrial production.

关 键 词：洋茉莉醛 缩合 氧化 合成 

分 类 号：TQ65[化学工程—精细化工]