莫西沙星治疗老年社区获得性肺炎的疗效观察  

Clinical effect of moxifloxacin in the treatment of community acquired pneumonia in the elderly

作　　者：林阅生[1] LIN Yue-sheng(Quanzhou Guangqian Hospital,Fujian 362321,China)

机构地区：[1]福建省泉州市光前医院

出　　处：《临床合理用药杂志》2019年第20期13-15,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察老年社区获得性肺炎患者采用莫西沙星治疗的效果。方法将医院收治的老年社区获得性肺炎患者140例,随机分为观察组和对照组,每组70例。观察组采用莫西沙星治疗,对照组采用左氧氟沙星治疗。比较2组药物治疗有效率、细菌根除率、不良反应发生率,分析治疗成功和失败的相关因素。结果观察组数据优势显著,药物治疗有效率、细菌根除率、患者机体不良反应发生率等各项指标均优于对照组(P<0.05)。对观察组药物治疗有效和无效的相关病因素进行分析发现,患者出现水电解质紊乱、合并2种及以上慢性病、肾功能不全、血肌酐含量以及年龄偏大、长期卧床休息,患病几率较大(P<0.05);患者吸烟、白细胞计数等因素对致病无影响(P>0.05)。结论莫西沙星治疗老年社区获得性肺炎患者效果确切,可有效清除致病菌,安全性较高。同时,临床可针对可能引发该病的各种因素进行综合评估,以制定有效策略,进一步提高治愈率和改善预后。Objective To observe the effect of moxifloxacin on elderly patients with community acquired pneumonia.Methods 140 elderly patients with community acquired pneumonia were randomly divided into observation group and control group,70 cases in each group.The observation group was treated with moxifloxacin,while the control group was treated with levofloxacin.The effective rate of drug treatment,bacterial eradication rate and incidence of adverse reactions were compared between the two groups,and the related factors of treatment success and failure were analyzed.Results The data advantage of the observation group was significant,and the effective rate of drug treatment,bacterial eradication rate and the incidence of adverse reactions of patients were better than those of the control group(P<0.05).The analysis of the effective and ineffective phases of pathogenic factors in the observation group showed that patients with water and electrolyte disorders,combined with two or more chronic diseases,renal insufficiency,serum creatinine content,and older age were more likely long-term bed rest had to develop the disease(P<0.05).Smoking and white blood cell count no effect on the pathogenesis(P>0.05).Conclusion Moxifloxacin is effective and safe in the treatment of elderly patients with community acquired pneumonia.At the same time,clinical evaluation of various factors that may cause the disease can be carried out to formulate effective strategies to further improve the cure rate and prognosis.

关 键 词：莫西沙星 老年社区获得性肺炎 细菌根除率 不良反应 

分 类 号：R47[医药卫生—护理学]