溻洗散治疗足癣的临床疗效观察及体外抑菌实验研究  

Clinical observation and drug sensitivity test of TaXi power in the treatment of tinea pedis

作　　者：赵一丁 田改苗 孙丹 闫小宁 ZHAO Yi-ding;TIAN Gai-miao;SUN Dan;YAN Xiao-ning(Department of Dermatology,Shaan xi Traditional Chinese Medicine Hospital,Xi’an 710003,China)

机构地区：[1]陕西省中医医院皮肤科

出　　处：《中国真菌学杂志》2019年第4期240-244,共5页Chinese Journal of Mycology

基　　金：陕西省难治性皮肤病中药新药研发创新团队(2017KCT-27)

摘　　要：目的探讨中药溻洗散治疗足癣的临床疗效及其对常见浅部真菌的抑制作用。方法入组167例足癣患者,随机分为试验组83例,对照组84例。试验组外用溻洗散联合硝酸舍他康唑乳膏,对照组外用硝酸舍他康唑乳膏,2次/d,疗程4周,于治疗前、治疗4周、停药2周时评价两组临床症状和体征评分、起效时间、总有效率、真菌清除率等。采用微量稀释法测定溻洗散对红色毛癣菌、须癣毛癣菌和白念珠菌的最低抑菌浓度。结果试验组与对照组总有效率分别为92.8%、82.1%,两组比较差异有统计学意义(P<0.05),试验组起效时间短于对照组(P<0.01)、真菌清除率高于对照组(P<0.05)。溻洗散对体外培养白念珠菌、红色毛癣菌和须癣毛癣菌均有抑制作用,MIC分别为0.125 g/mL、0.5 g/mL和0.25 g/mL。结论溻洗散治疗足癣临床疗效确切,对常见皮肤浅部真菌具有抑制作用,可在临床推广和应用。Objective To investigate the clinical curative effect and fungal clearance effect of Chinese medicine TaXi power in the treatment of tinea pedis.Methods One hundred and sixty-seven cases were randomly divided into two groups.The treatment group included 83 cases were treated by TaXi power liquid and sertaconazole nitrate cream topically twice a day for 4 weeks.The control group included 84 cases were treated by sertaconazole nitrate cream topically twice a day for 4 weeks.Visits were scheduled on preliminary diagnosis,4,6 weeks after treatment.The scores of the symptoms and signs,the effect onset time,the effective rate and the fungal clearance rate were compared respectively.The minimum inhibitory concentrations of Trichophyton rubrum,Trichophyton mentagrophytes and Candida albicans were tested by microdilution method.Result The effective rate of the treatment group was 92.8%.The effective rate of the control group was 82.1%.There were significant differences between the two groups(P<0.05).The effect onset time of the treatment group was shorter than that of the control group(P<0.05).The fungal clearance rate of the treatment group was higher than that of the control group(P<0.05)TaXi power had inhibitory effects on Candida albicans,Trichophyton rubrum and Trichophyton mentagrophytes in vitro.The MICs were 0.125 g/mL,0.5 g/mL and 0.25 g/mL.Conclusion TaXi power in the treatment of tinea pedis has exactly clinical curative effect.It has an inhibitory effect on common superficial fungi,and it can be promoted and applied in clinic.

关 键 词：溻洗散 硝酸舍他康唑 足癣 

分 类 号：R756.3[医药卫生—皮肤病学与性病学]