脓毒症急性肾损伤:一种微循环疾病  

Sepsis-induced acute kidney injury:a disease of the microcirculation

作　　者：刘丽霞[1] 王小亭[2] 晁彦公 张宏民[2] 武钧[4] 尹万红[5] 张丽娜[6] 何伟[7] 朱然[8] 丁欣[2] 张倩[1] 胡振杰[1,10,11,12,13,14,15,16] 无 Liu Lixia;Wang Xiaoting;Chao Yangong;Zhang Hongmin;Wu Jun;Yin Wanhong;Zhang Lina;He Wei;Zhu Ran;Ding Xin;Zhang Qian;Hu Zhenjie;无(Departmentof Critical Care Medicine,the Fourth Hospital of Hebei Medical,Shijiazhunag 050011,China;Departmentof Critical Care Medicine,Peking Union Medical College Hospital,Beijing 100730,China;Department of Critical Care Medicine,the First Hospital of Tsinghua University,Beijing 100010,China;Department of Critical Care Medicine,West China Hospital of Sichuan University,Chengdu 610041,China;Department of Intensive Care Unit,Xiangya Hospital Central South University,Changsha 410008,China;Department of Critical Care Medicine,Beijing Tongren Hospital,Beijing 100730,China;Department of Critical Care Medicine,Ruijin Hospital Afiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Critical Care Medicine,the First Hospital of China Medical University,Shenyang 110001,China;Chinese Critical Ultrasound Study Group)

机构地区：[1]河北医科大学第四医院重症医学科,河北石家庄050011 [2]北京协和医院重症医学科,北京100730 [3]清华大学第一附属医院重症医学科,北京100016 [4]上海交通大学医学院附属瑞金医院重症医学科,上海200025 [5]四川大学华西医院重症医学科,四川成都610041 [6]中南大学附属湘雅医院重症医学科,湖南长沙710008 [7]北京同仁医院重症医学科,北京100730 [8]中国医科大学附属第一医院重症医学科,辽宁沈阳110001 [9]中国重症超声研究组 [10]中国病理生理科学会危重病医学专业委员会 [11]中华医学会重症医学分会 [12]中国医师协会重症医学医师分会 [13]河北省医学会重症医学分会 [14]河北省医师协会重症医学医师分会 [15]河北省重症医学质量管理与控制中心 [16]石家庄市医学会重症医学分会

出　　处：《临床荟萃》2019年第7期595-598,共4页Clinical Focus

摘　　要：脓毒症急性肾损伤(acute kidney injury,AKI)时肾脏大循环和微循环呈现分离现象,肾脏血流正常甚至增加,而肾脏微循环缺血缺氧,表现为肾脏内血流分流,微循环灌注呈现异质现象,及微循环血流淤滞和梗阻,说明脓毒症AKI是一种微循环疾病,以微循环灌注为目标导向的治疗可能是今后的方向。The renal hemodynamics in sepsis induced acute kidney injury(AKI)is characterized by renal macro-and microcirculation separation.In such case,renal blood flow is normal or even enhanced,while the renal microcirculation is in a state of ischemia and hypoxia because of the intrarenal blood shunt,heterogeneity,stasis and obstruction.This phenomenon suggests that septic AKI belongs to microcirculation disease,and“microcirculation perfusion guided”strategy should be a therapeutic goal in future.

关 键 词：脓毒症 急性肾损伤 

分 类 号：R631[医药卫生—外科学]