内皮细胞特异性分子-1在冠心病非心肌梗死患者血清中的表达  

Expression of endothelial cell specific molecule-1 in serum of non-myocardial infarction patients with coronary heart disease

作　　者：朱宗成[1] 金骁琦[1] 郑冠群[1] 陈志贤[1] 金静[1] Zhu Zongcheng;Jin Xiaoqi;Zhen Guanqun;Chen Zhixian;Jin Jing(Department of Cardiology,Changshu Second People's Hospital,Suzhou 215500,China)

机构地区：[1]常熟市第二人民医院心内科

出　　处：《临床荟萃》2019年第7期626-628,共3页Clinical Focus

摘　　要：目的探讨内皮细胞特异性分子-1(ESM-1)在冠心病非心肌梗死患者血清中的表达及其意义。方法选择40例冠心病非心肌梗死患为观察组,40例非冠心病患者为对照组。检测观察组和对照组所有患者血清中的ESM-1和冠心病相关炎性因子水平。探讨ESM-1含量和炎性因子与冠心病的相关性。结果两组血清中的ESM-1含量和冠心病相关炎性因子水平相比具有明显的差异(P<0.001)。多重线性回归分析显示,ESM-1与炎性因子VCAM-1、TNF-α、IL-8呈明显的正相关(P<0.001)。结论冠心病非心肌梗死患者血清中的ESM-1和炎性因子水平的升高对冠心病的发生起重要作用。Objective To investigate the expression and significance of endothelial cell specific molecule-1(ESM-1)in serum of non-myocardial infarction patients with coronary heart disease(CHD).Methods Forty patients of CHD with non-myocardial infarction were selected as observation group,and 40 patients with non-CHD as control group.The serum levels of ESM-1 and inflammatory factors related to CHD in all patients.The relationship between ESM-1 content and inflammatory factors with CHD was explored.Results There were significant differences in the levels of ESM-1 and inflammatory factors related to CHD between two groups(P<0.001).Multiple linear regression analysis showed that ESM-1 was positively correlated with inflammatory factors VCAM-1,TNF-αand IL-8(P<0.001).Conclusion The elevated levels of ESM-1 and inflammatory factors in serum of non-myocardial infarction patients with CHD play an important role in the occurrence of CHD.

关 键 词：冠状动脉疾病 内皮生长因子 细胞因子类 

分 类 号：R541.4[医药卫生—心血管疾病]