肝脏组织炎症程度与血清HBeAg定量的相关性研究  

Association study between liver inflammation and HBeAg quantification

作　　者：朱萍 路毓峰 王丽[4] 王红 杨莉[3] 卢建华[3] 李敏然[2] 叶立红[3] 陈秀丽[2] Zhu Ping;Lu Yufeng;Wang Li;Wang Hong;Yang Li;Lu Jianhua;Li Minran;Ye Lihong;Chen Xiuli(Department of Laboratory,the Sixth Hospital of Shijiazhuang,Shijiazhuang 050000,China;Department of infection,Shijiazhuang Fifth Hospital,Shijiazhuang,Hebei Province,050000;Laboratory of the Fifth Hospital of Shijiazhuang,Hebei,050000;Department of Oncology,the Affiliated Hospital of Hebei University of Technology,Handan 056000,China)

机构地区：[1]石家庄市第六医院检验科,河北石家庄050000 [2]石家庄市第五医院感染科,河北石家庄050000 [3]石家庄市第五医院检验科,河北石家庄050000 [4]河北工程大学附属医院肿瘤科,河北邯郸056000

出　　处：《临床荟萃》2019年第7期637-640,共4页Clinical Focus

基　　金：河北省2018年度医学科学研究重点课题计划资助项目——乙肝五项定量检测在慢性HBV感染者临床意义研究(20181079)

摘　　要：目的探讨HBeAg阳性慢性乙型肝炎(chronic hepatitis B,CHB)患者肝脏组织炎症程度与血清HBeAg定量的相关性。方法 296例HBeAg阳性CHB患者,在超声引导下进行肝穿刺活检,根据慢性病毒性肝炎炎症活动度(grade,G)标准计分,肝活检当天采集静脉血后分离血清,化学发光免疫分析系统进行HBeAg定量检测,根据血清HBeAg定量分为3个亚组。结果 随着肝脏炎症活动度G1、G2、G3/G4的进展,血清HBeAg定量水平逐渐下降,HBeAg定量与患者肝脏组织炎症程度之间存在显著负相关(r=-0.513,P <0.01)。结论 HBeAg定量有望作为判断肝组织炎症程度的非创伤性诊断指标。Objective To discuss the correlation of chronic hepatitis B patients between liver inflammation and serum HBeAg quantification.Methods All 296 HBeAg-positive CHB patients received liver biopsy under ultrasound guidance,the scoring was based on viral hepatitis inflammatory activity standard(grade,G),and serum HBeAg quantification were quantified after serum was isolated on the same day.The three subgroups were divided according to the serum HBeAg quantification.Results Along with the progress of liver inflammation from G1 to G2,G3/G4,serum HBeAg level gradually decreased,the serum HBeAg quantification had negative correlation with liver inflammation(r=-0.513,P<0.01).Conclusion HBeAg quantification may become a non-invasive diagnostic marker of liver inflammation degree in CHB patients.

关 键 词：肝炎 乙型 慢性 炎症 肝炎e抗原 乙型 

分 类 号：R512.62[医药卫生—内科学]