支气管镜下肺泡灌洗液半乳甘露聚糖试验联合（1,3）-β-D葡聚糖检测对肺曲霉菌病的诊断价值  

Diagnostic value of BALF GM test combined with G test under bronchoscope for pulmonary aspergillosis

作　　者：潘玲[1] 卢岳虹 宋策[1] 谭玉萍[1] 冯原[1] 杨红梅[1] 陆彩云[1] 杨益宝[1] 梁炜[1] 冯玉清 苏齐鉴[1] 罗珍贞 Ling Pan;Yue-hong Lu;Ce Song;Yu-ping Tan;Yuan Feng;Hong-mei Yang;Cai-yun Lu;Yi-bao Yang;Wei Liang;Yu-qing Feng;Qi-jian Su;Zhen-zhen Luo(Department of Respiratory Medicine,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning,Guangxi 530001,China)

机构地区：[1]广西中医药大学附属瑞康医院呼吸内科

出　　处：《中国内镜杂志》2019年第8期5-9,共5页China Journal of Endoscopy

基　　金：广西壮族自治区卫生厅自筹经费科研课题（No:Z2013226）

摘　　要：目的探讨支气管镜下肺泡灌洗液(BALF)半乳甘露聚糖(GM)试验联合(1,3)-β-D葡聚糖检测(G试验)对肺曲霉菌病的诊断价值。方法选取2013年5月-2016年12月在该院住院的30例确诊为肺曲霉菌病的患者作为研究对象,定为研究组,30例非真菌感染患者为对照组,所有患者均支气管镜下采集BALF,并同时采集血清标本进行GM试验和G试验,比较单独和联合试验的检测结果。结果研究组中,BALF GM试验阳性21例,G试验阳性25例;血清GM试验阳性19例,G试验阳性23例;BALF GM联合G试验阳性27例;血清GM联合G试验阳性26例。BALF GM试验联合G试验检测灵敏度、特异性、阳性预测值、阴性预测值和准确度分别为90.0%、93.3%、93.1%、93.3%和91.0%。结论支气管镜下BALF GM试验联合G试验检测对肺曲霉菌病的诊断临床价值高,可作为诊断肺曲霉菌病的重要辅助诊断手段。Objective To investigate the diagnostic value of BALF GM test combined with G test under bronchoscope in the diagnosis of pulmonary aspergillosis.Methods 30 patients with pulmonary aspergillosis from May 2013 to December 2016 were selected as study group and 30 patients with non-fungal infection were selected as control group.All the patients were collected from alveolar lavage fluid(BALF)under bronchoscope and serum samples were collected for galactomannan test(GM test)and 1,3-β-D-glucan test(G test).Results In the study group,21 cases were positive for GM test in alveolar lavage fluid,25 cases were positive for G test,19 cases were positive for serum GM test,23 cases were positive for G test,27 cases were positive for GM combined with G test in alveolar lavage fluid,and 26 cases were positive for serum GM combined G test;The sensitivity,specificity,positive predictive value,negative predictive value and accuracy of bronchoalveolar lavage fluid GM test combined with G test were 90.0%,93.3%,93.1%,93.3%and 91.0%,respectively.Conclusion BALF GM test combined with G test under bronchoscope is of high clinical value in the diagnosis of pulmonary aspergillosis and can be used as an important auxiliary diagnostic index for pulmonary aspergillosis.

关 键 词：支气管镜 肺泡灌洗液 半乳甘露聚糖 (1 3)-β-D-葡聚糖 肺曲霉菌病 

分 类 号：R563[医药卫生—呼吸系统]