B细胞信号通路相关基因单核苷酸多态性与系统性红斑狼疮的研究进展  

The research progress of single nucleotide polymorphism in B cell signaling pathway related genes and systemic lupus erythematosus

作　　者：杨英[1] 陈晓红[1] 杨莹[1] YANG Ying;CHEN Xiao-hong;YANG Ying(Department of Dermatology,Affiliated hospital of Zunyi Medical College,Zunyi 563003,Chin a)

机构地区：[1]遵义医学院附属医院皮肤科

出　　处：《皮肤病与性病》2019年第4期497-500,共4页Dermatology and Venereology

基　　金：遵义市科技局(遵市科合社字[2014]84号);贵州省卫计委科学技术基金资助项目(gzwjkj2017-1-040);贵州省科技厅联合基金资助项目(黔科合LH字[2015]7474号)

摘　　要：系统性红斑狼疮是一种以多种自身抗体产生,导致炎症和器官损伤为特点的自身免疫性疾病。随着单核苷酸多态性成为新的遗传变异标志,其在系统性红斑狼疮易感性及临床表型方面起关键作用,目前研究证实,B细胞通路相关基因的单核苷酸多态性位点在不同种族、不同地区中与系统性红斑狼疮具有一定的相关性。Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by multiple autoantibody production,inflammation and organ damage.With the single nucleotide polymorphism(SNP)as a new genetic variation marker,it play a key role in susceptibility and clinical phenotype of SLE.Current studies have confirmed that SNP of genes related to B cell pathway have some correlation with SLE in different races and regions.

关 键 词：单核苷酸多态性 系统性红斑狼疮 B细胞通路 

分 类 号：R593.02[医药卫生—内科学] R563.241[医药卫生—临床医学]