广西孕产妇RhD阴性血型抗D抗体产生与新生儿溶血病的相关性分析  

A Correlative Analysis of RhD Negative Blood Type with Anti-D Antibodies and Hemolytic Diseases of Newborns (HDNs) in Guangxi District

作　　者：卢春柳 苏建聪 黄剑 孙泽峰 周建月[1] LU Chun-liu;SU Jian-cong;HUANG Jian(The Second Hospital of Guangxi Medical University and Guangxi Medical Management Service Guidance Center,Guangxi 530021)

机构地区：[1]广西医科大学第二附属医院,530007 [2]广西壮族自治区医疗管理服务指导中心

出　　处：《临床输血与检验》2019年第4期345-347,共3页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：广西卫计委自筹课题（No.Z20181041）资助

摘　　要：目的了解广西南宁、贵港、百色三地孕产妇RhD阴性血型分布、抗D抗体产生及因抗D抗体而导致新生儿溶血病(hemolytic disease of the newborn,HDN)的情况,合理指导当地RhD阴性血型孕产妇孕期健康宣教、生育质量及输血安全。方法采用血型卡和试管法对三地2016年1月~2018年5月的产科门诊及产科住院孕产妇共96 471人进行RhD血型鉴定及不规则抗体检查,对出生怀疑为HDN的新生儿进行溶血三项实验。结果三地共检出RhD阴性血型孕产妇304例,阴性率0.32%(304/96 471),在304例RhD阴性血型中检出7例抗D抗体,占RhD阴性血型的2.30%(7/304),在7例有抗D抗体的孕产妇所分娩的新生儿中有5例发生HDN,占检出抗D抗体的71.43%。结论广西三地孕产妇RhD阴性血型分布频率存在差异,妊娠胎次与抗D抗体产生的能力也存在差异,因抗D抗体的产生而引起新生儿溶血病的百分率也有差异。Objective To analyze the characteristic of RhD negative blood type and anti-D antibodies and their association with hemolytic diseases of newborns(HDNs)in Nanning,Guigang and Baise regions of Gua ngxi province.Methods A total of 96 471 samples from pregnant women with no blood transfusion were tested with blood type cards and tube testing.Results 304 samples(0.32%)of RhD-negative blood were found in the pregnant woman and 7 of them had cotest with anti-D antibodies(2.30%),among them,5 newborns(71.43%)suffered from HDNs.Conclusion The distribution frequency of RhD negative blood type varied in regions of Guangxi,with different frequencies of positive anti-D antibodies that may be associated with hemolytic diseases of infants.

关 键 词：RHD阴性血型 孕产妇 抗D抗体 新生儿溶血病 

分 类 号：R457.11[医药卫生—治疗学] R556.6+3[医药卫生—临床医学]