地塞米松联合咖啡酸片治疗ITP患者对PAIgG及GPⅡb/Ⅲa抗体的影响  

The Effect of Dexamethasone Combinated with Caffeic Acid Tablet on PAIgG and GPⅡb/Ⅲa Levels in Patients with Primary Immune Thrombocytopenia

作　　者：徐丹[1] 计成阜[1] 陈超[1] 姜金龙[1] 刘鑫[1] 王萍[1] 周海侠[2] XU Dan;JI Cheng-fu;CHEN Chao(Department of Hematology,Funing Hospital of Yancheng,Jiangsu 224400)

机构地区：[1]江苏省盐城市阜宁县人民医院血液科,224400 [2]苏州大学附属第一医院血液科

出　　处：《临床输血与检验》2019年第4期368-371,共4页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：江苏省盐城市医学科技发展计划项目（No.YK2017070）资助

摘　　要：目的探讨地塞米松联合咖啡酸片治疗原发性免疫性血小板减少症(primary immune thrombocytopenia,ITP)对患者血小板相关抗体(platelet-associated immunoglobulin,PAIgG)及GPⅡb/Ⅲa抗体水平的影响.方法将2014年8月~2017年3月本院收治的ITP患者80例随机分为2组,观察组与对照组各40例,其中对照组患者服用地塞米松,观察组服用地塞米松及咖啡酸.对比两组治疗效果、PAIgG及GPⅡb/Ⅲa抗体水平的差异.结果两组患者治疗14 d、28 d、12 w后CR、R及NR人数比例间的差异无统计学意义;治疗前,两组出血评分、PAIgG及GPⅡb/Ⅲa抗体水平的组间差异无统计学意义(P>0.05).治疗后,两组出血评分、PAIgG及GPⅡb/Ⅲa抗体水平明显低于治疗前(P<0.05);其中,观察组出血评分[1(0~3.5)vs 2(0~5)]分、PAIgG阳性血小板百分率[(25.52±7.21)vs(36.18±8.79)]%、GPⅡb/Ⅲa抗体水平[(16.77±2.15)vs(21.49±1.58)]明显低于对照组(P均<0.05).结论地塞米松联合咖啡酸片治疗ITP患者与单独服用地塞米松组相比,疗效差异无统计学意义,但药物合用可有效改善患者出血症状,降低PAIg G及GPⅡb/Ⅲa抗体水平.Objective To investigate the effect of dexamethasone(DX)combinated with caffeic acid tablet(CAT)on PAIg G and GPⅡb/Ⅲa levels in patients with primary immune thrombocytopenia(ITP).Methods Eighty patients with ITP in the hospital were selected from August 2014 to March 2017 and randomly divided into two groups,with 40 cases in each.The control group only received CAT,while the observation group was given DX and CAT.Clinical efficacy and PAIg G and GPⅡb/Ⅲa levels were compared between the two groups.Results The CR,R and NR rates did not reveal any significant difference on d1 4,d2 8 and w1 2 after treatments.Similarly,the bleeding score,PAIg G and GPⅡb/Ⅲa levels showed no remarkable differences before treatments(P>0.05)but obviously decreased after treatments in the observation group compared with the control(P<0.05).Conclusion Compared with dexamethasone treatment,dexamethasone combined with caffeic acid tablet did not improve the therapeutic outcomes in the treatment of ITP patients in terms of laboratory tests.However,the combination therapy can effectively ameliorate the bleeding symptoms and reduce the antibody levels of PAIg G and GPⅡb/Ⅲa.

关 键 词：地塞米松咖啡酸原发性免疫性血小板减少症 PAIGG GPⅡb/Ⅲa 

分 类 号：R5582[医药卫生—血液循环系统疾病] R446.11[医药卫生—内科学]