血浆IgE和细胞结合IgE水平检测在过敏性疾病中的应用价值  

Application value of detection of plasma IgE and cell bound IgE levels in allergic diseases

作　　者：丘创华[1] 钟丽红[2] 李卓成[1] 佘吉佳[1] 虎子单 QIU Chuanghua;ZHONG Lihong;LI Zhuocheng;SHE Jijia;HU Zidan(Department of Laboratory,second people's Hospital of Shenzhen City,Guangdong Province,Shenzhen 518000,Guangdong Province;Department of cadre Health,second people's Hospital of Shenzhen,Guangdong Province,Shenzhen 518000,Guangdong Province)

机构地区：[1]广东省深圳市第二人民医院检验科,广东深圳518000 [2]广东省深圳市第二人民医院干部保健科,广东深圳518000

出　　处：《检验医学与临床》2019年第16期2313-2315,共3页Laboratory Medicine and Clinic

基　　金：广东省深圳市科技创新委员会课题(JCYJ2016042510332307)

摘　　要：目的分析过敏性疾病患者血浆免疫球蛋白E(IgE)和细胞结合IgE水平,为过敏性疾病的诊断提供依据。方法选取2018年1-12月就诊于该院的过敏性疾病患者179例及同期健康体检者50例为研究对象,采用电化学发光法对血浆IgE及细胞结合IgE水平进行检测。结果细胞结合IgE检测对过敏性疾病的诊断价值优于血浆IgE,细胞结合IgE鉴别过敏性疾病的最佳临界值为360 ng/mL,灵敏度为87.2%,特异度为82.1%。室温放置对细胞结合IgE水平的影响小于血浆IgE。结论与血浆IgE相比,细胞结合IgE水平更稳定,对过敏性疾病的诊断价值更大。Objective To analyze the plasma IgE and cell bound IgE levels in the patients with allergic diseases to provide a basis for the diagnosis of allergic diseases.Methods A total of 179 patients with allergic diseases and contemporaneous 50 healthy control individuals in this hospital from January to December 2018 were selected.Plasma IgE and cell bound IgE levels were detected by adopting the electrochemiluminescence method.Results The detection of cell bound IgE level in the diagnosis of allergic diseases was superior to plasma IgE.The optimal critical value of cell bound IgE in the identification of allergic diseases was 360 ng/mL,with a sensitivity of 87.2%and a specificity of 82.1%.The effect of room temperature place on cell bound IgE level was less than that of plasma IgE level.Conclusion Compared with plasma IgE,the stability of cell bound IgE level is better,and the IgE level has greater value to the diagnosis of allergic diseases.

关 键 词：细胞结合IgE 血浆IgE 受试者工作特征曲线 稳定性 

分 类 号：R446.6[医药卫生—诊断学]