某高校社区体检人群甲状腺回声改变与甲状腺血清学指标的相关性研究  

Research on correlation between thyroid echo changes and thyroid serological indexes in community physical examination population of a college

作　　者：陈艳铭[1] 黄刚[1] 张艳平[1] 汪俊汉[1] CHEN Yanming;HUANG Gang;ZHANG Yanping;WANG Junhan(Hospital of Huazhong University of Science and Technology,Wuhan,Hubei 430074,China)

机构地区：[1]华中科技大学医院

出　　处：《检验医学与临床》2019年第16期2329-2331,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨某高校社区体检人群甲状腺回声改变与甲状腺血清学指标的相关性。方法选取2017年1月至2018年6月在该院同时进行甲状腺彩超和甲状腺血清学检查的体检人群664例,根据彩超结果分为甲状腺回声改变组259例和甲状腺回声正常组405例,分别对两组进行甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平检测。结果甲状腺回声改变组TPOAb和(或)TGAb异常检出率为74.9%,明显高于甲状腺回声正常组,差异有统计学意义(P<0.05)。甲状腺回声改变组甲状腺功能异常检出率为23.2%。甲状腺回声改变与TPOAb、TGAb、TSH呈正相关(P<0.01),与FT4呈负相关(P<0.01),与FT3无相关性(P>0.05)。结论甲状腺回声改变与甲状腺自身抗体、TSH和FT4具有相关性。甲状腺回声改变时,甲状腺自身抗体水平明显升高,且罹患甲状腺功能异常疾病的风险增加。因此,同时进行甲状腺彩超和甲状腺血清学指标检测,对早期发现甲状腺疾病,降低甲状腺功能异常疾病的发生风险具有重大意义。Objective To investigate the correlation between the thyroid echo changes and thyroid serological indexes in community physical examination population of a college.Methods A total of 664 cases of physical examination population in this hospital from January 2017 to June 2018,who simultaneously conducted thyroid color ultrasound and thyroid serological examination,were selected and divided into the thyroid echoes change group(259 cases)and thyroid echoes normal group(405 cases)according to the color ultrasound results.Then the levels of thyroid peroxidase antibodies(TPOAb),thyroglobulin antibody(TGAb),TSH,FT3 and FT4 were detected in the two groups.Results The detection rate of TPOAb and(or)TGAb abnormality in the thyroid echoes change group was 74.9%,which was significantly higher than that in the thyroid echoes normal group,and the difference was statistically significant(P<0.05).The abnormality rate of thyroid function in the thyroid echoes change group was 23.2%.The thyroid echoes change had the positive correlation with the levels of TPOAb,TGAb,TSH(P<0.01),negative correlation with FT4(P<0.01),and had no correlation with the FT3 level(P>0.05).Conclusion The thyroid echo changes have the correlation with the thyroid autoantibodies,TSH and FT4.When the thyroid echoes are changed,the thyroid autoantibodies levels are significantly increased,moreover the risk suffering from the thyroid function abnormality disease is increased.Therefore simultaneously conducting thyroid color ultrasound examination and thyroid serological indexes detection has an important significance for early discovering the thyroid diseases and reducing the occurrence risk of thyroid function abnormality diseases.

关 键 词：甲状腺 回声改变 甲状腺过氧化物酶抗体 甲状腺球蛋白抗体 促甲状腺激素 游离三碘甲状腺原氨酸 游离甲状腺素 

分 类 号：R446.1[医药卫生—诊断学]