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作 者:李秀杰 LI XiuJie(Jiamusi Tuberculosis Prevention and Control Hospital,Jiamusi 154007 Heilongjiang,China)
机构地区:[1]佳木斯市结核病防治院
出 处:《中国民康医学》2019年第12期8-10,共3页Medical Journal of Chinese People’s Health
摘 要:目的:观察胸腺五肽联合抗结核药物治疗方案与单纯抗结核药物治疗方案对复治涂阳结核病的效果及对患者机体免疫功能的影响。方法:选取86例复治涂阳结核病患者作为研究对象,按照随机数字表法将其分为对照组与研究组各43例。对照组给予单纯抗结核药物治疗,研究组在对照组的基础上联合胸腺五肽治疗,比较两组临床疗效、治疗前后免疫指标水平及不良反应的发生情况。结果:研究组的治疗有效率为88.37%(38/43),明显高于对照组的67.44%(29/43),差异有统计学意义(P<0.05);研究组痰菌转阴率、病灶吸收率、肺部空洞闭合率均明显高于对照组,差异均有统计学意义(P<0.05);治疗后,两组CD4^+、CD4^+/CD8^+均较治疗前升高,CD8^+均较治疗前下降,且研究组各项指标均明显优于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为18.60%(8/43),与对照组的13.95%(6/43)比较,差异无统计学意义(P>0.05)。结论:胸腺五肽联合抗结核药物治疗方案可明显提高复治涂阳结核病患者的免疫水平,效果明显优于单纯应用抗结核药物方案。Objective: To observe effects of Thymopentin combined with anti-tuberculosis drugs and simple anti-tuberculosis drugs on retreated smear-positive pulmonary tuberculosis and their influences on the patients’immune function.Methods:86 patients with retreated smearpositive pulmonary tuberculosis were selected as the study subjects,and were divided into control group(n=43)and study group(n=43)according to the random number table method.The control group was treated with anti-tuberculosis drugs alone,while the study group was given Thymopentin treatment on the basis of that of the control group.The clinical efficacy,the level of immune indicators before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The effective rate of the study group was 88.37%(38/43),which was significantly higher than that of the control group(67.44%,29/43),and the difference was statistically significant(P<0.05).The sputum negative conversion rate,lesion absorption rate and lung cavity closure rate in the study group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CD4^+and CD4^+/CD8^+of the two groups were higher than those before the treatment,the CD8^+levels was lower than those before the treatment,and those of the study group were significantly better than those of the control group,and the differences were statistically significant(P<0.05).The incidences of adverse reactions in the study group and the control group were 18.60%(8/43)and 13.95%(6/43),respectively,and the difference was statistically significant(P<0.05).Conclusions:Thymopentin combined with the anti-tuberculosis drugs can improve the immune function of the patients with retreated smear-positive pulmonary tuberculosis.Moreover,its curative effects are better than single anti-tuberculosis drugs.
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